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EPIGENETIC FACTORS. “Epidemiological studies indicate that disruption of circadian rhythms in humans is associated to increased cancer risk (see above). In addition, pilot data now suggest that shift work can also regulate the epigenetic landscape, which could likely be a mechanism by which circadian gene expression is altered.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

“REALITY is a tiny fraction of the true "hyper-reality" which we picture as a Hilbert space.” https://lnkd.in/gDaxUYAS View in LinkedIn

SEMI-LUCID STATES. “Edison, Tesla, Poe, and Dalí each accessed this state by napping with a steel ball in hand, capturing creative ideas generated in hypnagogic microdreams when the ball crashed to the floor below.” https://t.co/0gjxLzj8RG View in LinkedIn

This remarkable self-taught mathematical artist achieved such expertise that he was corresponding with leading mathematicians like Roger Penrose and Coxeter. View in LinkedIn

JUMPING GENES. “Transposable elements (TEs) are selfish genetic units that typically encode proteins that enable their proliferation in the genome and spread across individual hosts. TE-derived proteins have been recurrently repurposed as part of defense systems that protect prokaryotes and eukaryotes against the proliferation of infectious or invasive agents, including viruses and TEs themselves.” https://lnkd.in/diFFwRZZ View in LinkedIn

MIND-WANDERING. “Until the mid-1990s, cognitive psychology and the emerging field of cognitive neuroscience were dominated by a task-centric view of mental processes. Experimental designs were carefully constructed to minimize the effects of task-unrelated thoughts that were generally viewed as experimental 'noise'.” (Excellent article). https://lnkd.in/eFtRGz4j View in LinkedIn

SO ENDS this first of two weekends on an article about the relationship of the cellular circadian clock to cancer formation from the epidemiological and genetic evidence. Strange work hours have long been considered unhealthy, but this review compellingly suggests that it is actually carcinogenic. It is curious that it involves the circadian clock, and that it is so delicately balanced between health and disease. View in LinkedIn

GENE REWIRING. “It is thus tempting to speculate that a rewiring could take place during tumorigenesis, whereby the balance of clock-controlled transcription can be lost and consequently compensated for by oncogenic MYC signaling.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

“CLOCK, BMAL1, and MYC are all transcription factors that share a highly similar basic helix-loop-helix (bHLH) protein domain, allowing these proteins to recognize the same promoter element, the enhancer box (E-box) sequence, in the regulatory regions of target genes.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

VALIDATION. “These findings in cells cultured in vitro have been further validated in vivo via genetically engineered mice.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn