DEFECTIVE INTERFERING (DI) “genomes are synthesized by nearly all known viruses and represent a vast natural reservoir of antivirals…during successive undiluted passages, the yield of infectious virus cycled from high to low…non-infectious virus particles resulted from large (up to 90%) deletions in one or more of the eight viral genome segments. In the presence of these defective particles the production of infectious virus is severely diminished and this led to the designation of the mutants as defective interfering (DI) viruses.”
https://lnkd.in/egCZeY2
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022