VIRAL STRATEGIES. “Viruses seem to have evolved strategies to efficiently adapt to the scale-free and small-world architecture of the human interactome. By interacting with host hubs, viruses target the “Achilles’ heel” of the host interactome. Because of the multi-functionality of these hubs, viruses manipulate a wide range of functions. In addition, some viral proteins have also evolved the ability to interact with numerous cellular proteins.”
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