TRYPTOPHAN STARVATION. “The ability for the host to modulate nutrient pools is not only a property that the parasite may co-opt but also represents a critical mechanism for the host to restrict parasite growth. As an example, a key IFNγ effector gene in humans is indoleamine dioxygenase that functions to catabolize tryptophan, which the parasite cannot synthesize de novo. Thus, tryptophan starvation is a critical anti-toxoplasmotic pathway in some but not all hosts.”
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0463.2009.02453.x/full
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022