PARTIAL ANSWER. “Even the ENCODE project, looked at a relatively small number of cell types. There are many transient progenitor cell populations whose epigentic marks are not yet described. So I really would not waste much thought about whether it is 8% or 80% functional. I would say there is likely to be remnants of DNA from transposons, gene duplications, pseudogenes etc. But how much of this is truly non-functional remains unknown.”
https://lnkd.in/e_se8kz