SELF-DAMAGE. “The observed maternal predominance in uniparental transmission is due to a higher mutational load of paternal cytotypes, which in turn is caused by oxidative damage and/or genetic drift and is most pronounced if oDNA copy numbers in the sperm cell are small. The load is high enough to favor the evolution of paternal gamete-controlled organelle exclusion mechanisms (“killing one’s own cytoplasm”).” (oDNA = organelle DNA).
https://lnkd.in/d34vWHz
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022