SO ENDS this summary of Professor Denis Nobel’s thinking, as outlined in his book Dance to the Tune of Life. The central dogma of molecular biology was formulated by Francis Crick in 1958. Often stated as “DNA makes RNA and RNA makes protein”, in essence it states that once information gets into protein, it cannot get out again, and is unidirectional in flow, and information cannot flow from protein to protein or from protein to nucleic acid. Well, in the sixty years since this proposition, we have learned a lot, and the dogma has been modified.
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