STEPWISE EVOLUTION. “Extant metabolic pathways in general contain a set of enzymes catalyzing sequential reactions in a highly concerted manner. Given that the end metabolites of metabolic pathways ultimately confer selective advantages to the host, it is indeed difficult to understand how individual incipient enzymes arrive at specific activities over defined periods of time through stepwise evolution – Descent with Modification – before assembly of a more complex and integrated pathway.”
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