CASCADE REACTIONS. “Steroid and thyroid hormones, along with vitamins A and D, were elucidated based on their endocrine origin and the physiologic processes that they regulate. Each of these small molecules is chemically distinct, and although there was initially no presumption that they might have a shared signaling mechanism, initial biochemical experiments revealed the presence of an intracellular receptor that, upon ligand addition, activated transcription of tissue-specific sets of target genes.”
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