LETHAL TRAIT LOSS IN PLANKTON. “The so-called spiral determinate cleavage of many planktotrophic spiralian species so rigidly casts the fate of each embryonic cell early in the four- and eight-cell stage of embryo development that it is difficult (although not impossible) to imagine that mutations causing this embryology to deviate from the norm would be anything but lethal.”
http://aob.oxfordjournals.org/content/85/4/411.full.pdf