SHIMMERING CHANGES. “Throughout development, the progressive diversification and differentiation of cells requires a constant reorganization of their underlying gene regulatory state. This progression is under the control of gene regulatory networks (GRNs) comprised of transcription factors controlling regulatory and effector proteins, ultimately resulting in the activation of the terminal cellular differentiation program.”
http://www.sciencedirect.com/science/article/pii/S0012160613004119