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EPIGENETIC FINGERPRINT. “On a genome-wide scale, 5,409 CpG sites were found to be differentially methylated in day-time versus night-time shift workers, and a remarkable 66% of these loci were hypermethylated. Similarly, CpG methylation of the PER1, PER2 and PER3 promoters was found to correlate with changes in protein expression in 50% of breast tumors versus normal tissue taken from the same patient.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

THE QUESTION. “Why were the two U-processes each dominated by superpositions moving outward from the Big Bang along the time dimension? Perhaps because at the Planck time, or any very early time, superpositions evolving backward in time would have very little potential duration, compared to many very long potential durations away from the origin.” https://lnkd.in/gDaxUYAS View in LinkedIn

EPIGENETIC METHYLATION. “For instance, in female shift workers from a prospective cohort in Denmark, DNA methylation studies have found genome-wide alterations to cancer-specific and circadian loci, including estrogen receptor α (ESR1) and the circadian genes clock (CLOCK) and cryptochrome 2 (CRY2).” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ORIGINS. “As part of this initial R-process which produced the Big Bang, the simplest assumption is that our universes have an R-process which proceeds indefinitely, to produce a single reality, which foliated spacetime in a double plane of simultaneity across the whole of the tiny universes at plus and minus the Planck time.” https://lnkd.in/gDaxUYAS View in LinkedIn

EPIGENETIC FACTORS. “Epidemiological studies indicate that disruption of circadian rhythms in humans is associated to increased cancer risk (see above). In addition, pilot data now suggest that shift work can also regulate the epigenetic landscape, which could likely be a mechanism by which circadian gene expression is altered.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

“REALITY is a tiny fraction of the true "hyper-reality" which we picture as a Hilbert space.” https://lnkd.in/gDaxUYAS View in LinkedIn

SEMI-LUCID STATES. “Edison, Tesla, Poe, and Dalí each accessed this state by napping with a steel ball in hand, capturing creative ideas generated in hypnagogic microdreams when the ball crashed to the floor below.” https://t.co/0gjxLzj8RG View in LinkedIn

This remarkable self-taught mathematical artist achieved such expertise that he was corresponding with leading mathematicians like Roger Penrose and Coxeter. View in LinkedIn

JUMPING GENES. “Transposable elements (TEs) are selfish genetic units that typically encode proteins that enable their proliferation in the genome and spread across individual hosts. TE-derived proteins have been recurrently repurposed as part of defense systems that protect prokaryotes and eukaryotes against the proliferation of infectious or invasive agents, including viruses and TEs themselves.” https://lnkd.in/diFFwRZZ View in LinkedIn

MIND-WANDERING. “Until the mid-1990s, cognitive psychology and the emerging field of cognitive neuroscience were dominated by a task-centric view of mental processes. Experimental designs were carefully constructed to minimize the effects of task-unrelated thoughts that were generally viewed as experimental 'noise'.” (Excellent article). https://lnkd.in/eFtRGz4j View in LinkedIn