LAG MECHANISM. “Jet lag operates by disrupting both circadian gene expression programs as well as circadian metabolism in the liver, and central to this rewiring is an induction of hepatic cholesterol and bile acid levels, which activate the oncogenic program of the nuclear receptor constitutive androstane receptor (CAR), and downstream activation of β-catenin.”
https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022