Month: September 2022

INHIBITING THE EFFECT. "Conversely, application of the growth regulatory hormone gibberellin or a loss-of-function mutation in the gibberellin-catabolizing enzyme AtGA2ox7 can prevent thigmomorphogenesis." https://lnkd.in/dv9swtZ View in LinkedIn

REPETITION SENSOR QUEST. "However, these effects are potentially far downstream in the pathway. No real known regulator of thigmomorphogenesis capable of sensing repetition has been identified yet." https://lnkd.in/dv9swtZ View in LinkedIn

STEREOTYPICAL RESPONSE. "Arabidopsis exhibits several stereotypical thigmomorphogenic responses that require multiple days of touch, including the inhibition of stem elongation, shortened petioles, reduced rosette diameter and delayed transition to flowering." https://lnkd.in/dv9swtZ View in LinkedIn

REGULATOR MUTANT SEARCH. "Here we concentrated on stem thigmomorphogenesis to identify new regulators of the touch response. We screened for plants that did not exhibit shortened stems after repeated touch." https://lnkd.in/dv9swtZ View in LinkedIn

CANDIDATE REGULATOR. "The first mutant isolated in this screen identified a known regulator of gene expression, the RNA Polymerase II-associated factor 1 (Paf1) complex, as a key element of thigmomorphogenesis that serves to integrate touch stimuli over time." https://lnkd.in/dv9swtZ View in LinkedIn

REGULATOR VALIDATION. "We show here that the Arabidopsis Paf1 complex is a critical factor for stem and root thigmomorphogenesis, stereotypical alterations in plant form that are made in response to repeated mechanical disturbance." https://lnkd.in/dv9swtZ View in LinkedIn

OTHER REGULATORS. "We also show that THS1/VIP3 is required for both global and genic levels of H3K36 methylation and for upregulation of two canonical touch-inducible loci in response to touch stimulation." https://lnkd.in/dv9swtZ View in LinkedIn

REGULATOR EVIDENCE. "We present four lines of evidence to support the conclusion that a lesion in VIP3 is responsible for the thigmomorphic defects seen in ths1 mutants." https://lnkd.in/dv9swtZ View in LinkedIn

BROAD EFFECTS OF REGULATORS. "These lines of evidence link VIP3 to stem thigmomorphogenesis. We also present evidence that other components of the Paf1 complex are required for thigmomorphic responses in both the stem and the root." https://lnkd.in/dv9swtZ View in LinkedIn

CONSERVED REGULATOR. "Given that the Paf1 complex is conserved across kingdoms and because animals also alter their body plan in response to repeated mechanical stresses, these findings also raise the possibility of a common mechanism for recording multiple mechanical deformations and translating them into developmental changes." https://lnkd.in/dv9swtZ View in LinkedIn