Month: September 2022

TRIUMPH OF DUPLICATION. "Speciation by genome duplication was recognized early in the study of evolutionary genetics and “represented the first major triumph in the genetics of speciation”. http://scholar.google.com/ View in LinkedIn

DEATH OF DE NOVO GENES. "The high rate of de novo gene birth in combination with a rather constant number of genes over time predicts that many of the de novo genes have only a short lifetime." http://www.sciencedirect.com/science/article/pii/S0168952515000347 View in LinkedIn

GRADUAL INTEGRATION. "The integration of new genes into GGI networks is a gradual evolutionary process. The new genes started, at a young age, to be integrated into networks to form new and less connected branches; however, with the elapse of evolutionary time, as genes grow older, they acquired more interacting links." (GGI = Gene-gene interaction networks)." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0772-4 View in LinkedIn

GENE CONNECTEDNESS. "New genes gradually evolve broader expression patterns and therefore acquire pleiotropic functions, as they gradually evolve more linking partners, and genes with more linking partners tend to have broader expression patterns." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0772-4 View in LinkedIn

ESSENTIAL GENES. "It has been reported that there is a relationship between gene topological features and biological functions. More specifically, genes with high network connectivity tend to be functionally essential." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0772-4 View in LinkedIn

NEW GENE FUNCTIONS. "It does not take many sequence changes to evolve a new function. For example, with only 3% sequence changes from its paralogues, RNASE1B has developed a new optimal pH that is essential for the newly evolved digestive function in the leaf-eating monkey." https://lnkd.in/dyvJr2S View in LinkedIn

GENE INTEGRATION. "Some de novo genes quickly become essential and persist for longer time spans. This raises the question of how de novo genes could become essential. The prevailing hypothesis is that de novo genes become integrated into already existing networks." http://www.sciencedirect.com/science/article/pii/S0168952515000347 View in LinkedIn

NEW GENE REGULATORS. "The first step is the integration into regulatory networks, primarily through acquisition of promoters. The analysis of retroposed genes indicated that regulatory elements can be acquired rapidly from nearby genes or more distant positions in the genome." http://www.sciencedirect.com/science/article/pii/S0168952515000347 View in LinkedIn

MATURING COMPLEXITY. "With increasing age of the regulatory landscape of de novo genes, a higher level of complexity is developed through the gradual acquisition of regulatory motifs." http://www.sciencedirect.com/science/article/pii/S0168952515000347 View in LinkedIn

SECOND LEVEL. "The integration of de novo genes into protein–protein interaction networks is significantly slower." http://www.sciencedirect.com/science/article/pii/S0168952515000347 View in LinkedIn