Month: September 2022

ANOTHER PERSPECTIVE. "However, the sheer abundance of TEs in the genome, as well as the variety of mutation effects induced by their mobility, suggest that they might, in some cases, be exapted or domesticated, to serve the evolutionary interests of the host." (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

POSITIVE ASPECTS. "Multiple lines of evidence indicate that the presence of TEs can result in host adaptation by shaping and reshaping the genome in many different ways." (TE = transposable elements). https://lnkd.in/dwuaM5f View in LinkedIn

MODIFIED STANDARD DOGMA. "Traditionally, genomes have been perceived mostly as repositories of protein-coding genes. Although this might be largely true in the case of viruses, prokaryotes, and unicellular eukaryotes, numerous recent studies on the genomes of multicellular eukaryotes, particularly animals, have revealed a vast non-coding RNome, i.e., numerous genes encoding various classes of non-coding RNAs (ncRNAs)." https://lnkd.in/dwuaM5f View in LinkedIn

GIANT CHUNKS OF NONCODING GENES. "The TEs comprise at least half of the mammalian genomes, and in particular, are found in most lincRNAs." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

PARALLEL UNIVERSE. "Here, we demonstrate that TEs substantially contribute to the evolution of lincRNAs and their promoter regions." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

TWO TRACK SYSTEM. “Viral-derived fossil genes, mostly non-functional, have contributed significantly to the vast universe of genes controlling non-coding RNAs, the parallel universe to the coding genes that have obsessed geneticists for decades. The parallel universe (noncoding) is virally-driven, fast evolving, more flexible, and may turn out to control many cellular functions.” https://lnkd.in/dwuaM5f View in LinkedIn

DIFFERENT RULES IN PARALLEL UNIVERSE. "The promoters of lincRNA appear to similarly enjoy greater plasticity and flexibility compared to the promoters of protein-coding genes." (LincRNA= long intergenic non-coding RNA). Meditate upon this. https://lnkd.in/dwuaM5f View in LinkedIn

DISTRIBUTION OF VIRAL FOSSILS. "Introns of lincRNA genes contain the highest percentage of TE-derived sequences (TES), followed by exons and then promoter regions although the density of TEs is not significantly different between exons and promoters." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

GENESIS. "Higher frequencies of ancient TEs in promoters and exons compared to introns implies that many lincRNA genes emerged before the split of primates and rodents." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

PREDOMINANCE IN PARALLEL UNIVERSE. "The content of TES in lincRNA genes is substantially higher than that in protein-coding genes, especially in exons and promoter regions." (TE = transposable elements; LincRNA= long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn