Month: September 2022

NEW VIEW NEEDED. "The paradigm shift in gene expression and regulation needs to be examined transcending the classical central dogma of molecular biology." View in LinkedIn

Ref for last post: Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation" "Munshi A1, Mohan V2,3* and Ahuja YR2 View in LinkedIn

NEW BIOLOGY. "The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets." https://lnkd.in/dn9zYG9 View in LinkedIn

JUNK DNA FOR COMPLEX NETWORKS. "Perhaps, the ncRNAs have evolved to enable the integration and networking of complex suits of gene-action to constitute a second tier gene-expression among eukaryotes. The proportion of ncRNA has linearly increased during evolution to suit the emergence of complex organisms of eukaryota." (ncRNA= Non coding RNA). View in LinkedIn

Ref for string: Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation" "Munshi A, Mohan V and Ahuja YR View in LinkedIn

"NON-CODING RNAs (ncRNAs) gained international attention in 1998, when the ability of a double stranded RNA to silence gene expression in Caenorhabditis elegans was discovered. For the discovery of such small ncRNAs that interfered with gene expression (RNAi), Andrew Fire and Craig Mellow won the Nobel Prize in Medicine and Physiology in 2006." View in LinkedIn

DOMINION. "Growing data have demonstrated that lncRNAs exhibit the greatest diversity among functional ncRNAs and play regulatory and structural roles in embryogenesis, stem cells pluripotency, allelic expression, protein-coding genes regulation, apoptosis, cycle control, growth, differentiation, and senescence." (LncRNAs = long non-coding RNAs; ncRNA= Non coding RNA). https://lnkd.in/d2sxUZQ View in LinkedIn

SECOND GENETIC CODE. "Discovery of a “second genetic code” consisting of ncRNAs has changed traditional concept of genomic organization characterized by presence of genes encoding islets scattered in a sea of ​​repeats and nontranscribed proteins. Recently, high-throughput techniques have identified 58648 human lncRNAs." (ncRNA = non coding RNA; lncRNA = long non coding RNA). https://lnkd.in/d8ucprw View in LinkedIn

SIMILAR MACHINERY. "There is no specific transcription of lncRNAs, the transcriptional machinery being common to lncRNAs and mRNAs. Lack of reading frame cannot also be a discriminating factor between mRNAs and ncRNAs because 50% of lincRNAs contain regions with high translational potential, comparable to those of mRNAs, suggesting that they are actively exported to cytoplasm and translated into short polypeptides, albeit certainly not active." (ncRNA = non coding RNA; lncRNA = long non coding RNA). https://lnkd.in/d8ucprw View in LinkedIn

UNCLASSIFIABLE. "Several mRNAs lose their ability to encode proteins (Xist) while others acquire coding function (SRA). Furthermore, by incorporating multiple exons from coding and noncoding genes, alternative splicing generates ambiguous transcripts beyond all classifications." https://lnkd.in/d8ucprw View in LinkedIn