Month: September 2022

FOUR TYPES of genetic conflict can occur. https://lnkd.in/gJtZbzC View in LinkedIn

GENOMIC CONFLICT 1: "gonotaxis (in which the selfish elements bias Mendelian segregation by moving away from dead-end polar bodies and into the functional egg during oogenesis, i.e., meiotic or centromeric drive)." http://cshperspectives.cshlp.org/content/7/3/a017608.full View in LinkedIn

GENOMIC CONFLICT 2: "interference (in which the selfish element kills or debilitates noncarrier gametes or offspring, i.e., segregation distortion and zygotic drive)." https://lnkd.in/gJtZbzC View in LinkedIn

GENOMIC CONFLICT 3: "overreplication (in which the selfish element increases its copy number in the genome, e.g., biased gene conversion, transposable elements, and homing endonucleases)." http://cshperspectives.cshlp.org/content/7/3/a017608.full View in LinkedIn

GENOMIC CONFLICT 4: "De novo mutations can also gain a transmission advantage by increasing the rate of stem cell division in the germ line (germline drive)." http://cshperspectives.cshlp.org/content/7/3/a017608.full View in LinkedIn

FOOTNOTE. ""Zygotic drive is an unusual form of genetic conflict because it directly reduces Darwinian fitness by killing or debilitating offspring. It is favored by gene-level selection when there is competition among siblings for limiting resources. By killing or weakening noncarrier competitor siblings, the gene(s) coding for zygotic drive gain a selective advantage because their survival is increased at the expense of siblings carrying alleles that are not identical by descent—despite any fitness loss to the parents, siblings, or other parts of the genome." http://cshperspectives.cshlp.org/content/7/3/a017608.full View in LinkedIn

DRIVER AND RESPONDER REQUIRED. "Zygotic drive of the autosomes has been observed in a wide diversity of model organisms (e.g., worms, beetles, and mice). In general, an autosomal zygotic driver must have both a driver allele at one locus and a protective allele at a responder locus." http://cshperspectives.cshlp.org/content/7/3/a017608.full View in LinkedIn

"REPETITIVE DNA forms a significant proportion of eukaryotic genomes. This is particularly evident in plants, which have faster genome dynamics than animals." https://lnkd.in/gdTbmHn View in LinkedIn

JUMPING GENES. "Even closely related species often significantly differ in composition of their transposable elements or satellites." https://lnkd.in/gdTbmHn View in LinkedIn

REPETITIVE DNA. "The chromosomal localization of repetitive DNA was previously thought to be only a result of selection, but recent findings show that other factors such as targeting of TEs into specific chromosomal niches are also important." (TE = transposable elements). https://lnkd.in/gdTbmHn View in LinkedIn