Month: September 2022

CHEMISTRY OF INFORMATION. “Supramolecular chemistry has developed as the chemistry of the entities generated by intermolecular noncovalent interactions. Through the appropriate manipulation of these interactions, it became progressively the chemistry of molecular information, involving the storage of information at the molecular level, in the structural features, and its retrieval, transfer, and processing at the supramolecular level, by interactional algorithms operating through molecular recognition events based on well-defined interaction patterns (hydrogen bonding arrays, sequences of donor and acceptor groups, ion coordination sites, etc.).” https://lnkd.in/dN969hA View in LinkedIn

PROGRAMMED MOLECULAR SYSTEMS. “Systems undergoing self-organization, i.e., systems capable of spontaneously generating well-defined, organized, and functional supramolecular architectures by self-assembly from their components, thus behaving as programmed systems.” https://lnkd.in/dN969hA View in LinkedIn

“CHEMICAL PROGRAMMING requires the incorporation into molecular components of suitable instructions for generation of a well-defined supramolecular entity. The program is molecular, the information being contained in the covalent structural framework; its operation is supramolecular, making use of recognition algorithms based on specific interaction patterns.” https://lnkd.in/dN969hA View in LinkedIn

FROM INANIMATE TO ANIMATE. “Understanding, inducing, and directing self-processes is key to unraveling the progressive emergence of complex matter. Self-organization is the driving force that led up to the evolution of the biological world from inanimate matter.” https://lnkd.in/dN969hA View in LinkedIn

ORGANIZED INFORMATION. “Whereas self-assembly may be taken as simple collection and aggregation of components into a confined entity, we shall here consider self-organization as the spontaneous but information-directed generation of organized functional structures in equilibrium conditions.” https://lnkd.in/dN969hA View in LinkedIn

“A SELF-ORGANIZATION PROCESS may be considered to involve three main stages: (i) molecular recognition for the selective binding of the basic components; (ii) growth through sequential and eventually hierarchical binding of multiple components in the correct relative disposition; it may present cooperativity and nonlinear behavior; and (iii) termination of the process, requiring a built-in feature, a stop signal, that specifies the end point and signifies that the process has reached completion.” https://lnkd.in/dN969hA View in LinkedIn

ON ENCODING AND ALGORITHMS. “Suitable encoding by manipulation of structural subunits and processing through interactional algorithms should give access to a variety of systems. More or less strict programming of the output species may be achieved depending on the robustness of a given directing code (for instance, of hydrogen bonding or metal coordination nature), i.e., on the extent to which it is sensitive to perturbations.” https://lnkd.in/dN969hA View in LinkedIn

OVERCOMING BACKGROUND INTERFERENCE. “In a robust system the instructions are strong enough for ensuring the stability of the process, i.e., the self-organization is resistant, stable toward interfering interactions (such as secondary metal coordination, van der Waals stacking, etc.) or toward modifications of parameters (such as concentrations and stoichiometries of the components, presence of foreign species, etc.).” https://lnkd.in/dN969hA View in LinkedIn

UNSTABLE DIVERSITY. “When the assembly occurs only in a narrow range of conditions, the system is unstable and presents a singularity; it may also display a bifurcation or a switching point between different assemblies. On the other hand, sensitivity to perturbations, while limiting the operation range, introduces diversity and adaptability in the self-organization process.” https://lnkd.in/dN969hA View in LinkedIn

CLEAR MESSAGES. “Self-selection with self-recognition occurs when the structural instructions are sufficiently strong, as is the case in the “correct” pairing of strands of different lengths in the assembly of helicates, inorganic double helices.” https://lnkd.in/dN969hA View in LinkedIn