Month: September 2022

NEW THINKING. “A paradigm shift, from “pure compounds” to “instructed mixtures”, from “unicity” to “multiplicity + information”.” https://lnkd.in/dN969hA View in LinkedIn

INSTRUCTED MIXTURES. “Rather than pursuing mere chemical purity of a compound or a material, one seeks to design instructed components, which, as mixtures, allow the controlled assembly of multiple well-defined supramolecular species, following specific programs and interactional algorithms.” https://lnkd.in/dN969hA View in LinkedIn

TOWARDS INSTRUCTED COMPLEXITY. “The implementation of this instructed mixture paradigm is crucial for the development of complex chemical systems, as witnessed by the build-up of organized species and the execution of highly integrated functions that take place side-by-side in the assembly and operation of the machinery of the living cell.” https://lnkd.in/dN969hA View in LinkedIn

KINETICS AND THERMODYNAMICS. “Because it is a time-dependent process, self-organization also involves temporal information and may display kinetic control, generating kinetic products before reaching the thermodynamic one(s). This is the case in the initial assembly of a triple helical complex that evolves toward a circular helicate.” https://lnkd.in/dN969hA View in LinkedIn

LIQUID CRYSTAL ASSEMBLY. ““Discotic liquid crystals form by the assembly of “sector”-shaped components into disks, which thereafter organize into columns, and template binding by molecular strands induces wrapping into helical disk-like objects, which then aggregate into large supramolecular assemblies.” https://lnkd.in/dN969hA View in LinkedIn

TOWARDS MULTIPLE-CODING. “The generation of a given superstructure through self-organization results, in its simplest form, from the operation of a single-code assembly program. A step beyond consists in devising systems of higher complexity that operate in multimode fashion through the implementation of several codes within the same overall program, resulting in multiple self-organization processes.” https://lnkd.in/dN969hA View in LinkedIn

OUTPUT IMPLICATIONS. “The processing of the same ligand information by different interaction algorithms (e.g., through the use of different sets of metal ions or of different H-bonding effectors) allows the controlled self-organization of different output architectures, resulting in multiple expression of molecular information, through postinformational (postgenomic!) operations. Such a one code/several outputs scheme, in addition to the one code/one output (product) mode, also has in principle significant implications in biology.” https://lnkd.in/dtRiQxQ View in LinkedIn

MOLECULAR COMPUTATION. “The combination of different recognition/instruction features in a molecular program opens a door to the design of self-organizing systems capable of performing molecular computation. Computing by self-assembly may yield a powerful alternative to conventional models. Recent studies described the use of biomolecules and DNA-based protocols to solve computational problems.” https://lnkd.in/dN969hA View in LinkedIn

MOLECULAR EVOLUTION. “Whereas preorganization relies entirely on design, supramolecular self-organization introduces in addition the possibility to let the system build up by selection.” https://lnkd.in/dN969hA View in LinkedIn

“SELF-ORGANIZATION BY DESIGN has been pursued with the goal to achieve full control over the output supramolecular entity by means of correctly instructed components, specific interaction algorithms, and (as much as possible) strict programming. Design is knowledge-based and has an explicit information content.” https://lnkd.in/dN969hA View in LinkedIn