Month: September 2022

UNRESOLVED ISSUES. “While it is rare that cataloguing mutations in cancer alone will reveal both mechanisms of disease progression and potential drugable targets, we are left with the greater challenge of understanding how some cancers can relapse after treatment.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

“ONE POSSIBLE SOLUTION is the use of network concepts to identify groups of genes that when perturbed give the same phenotype and hence form a disease module.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

THE HOPE. “If systems biology can rise to the challenge of predicting the mutations that are most likely to allow a cancer to relapse, we may be able to design multi-drug treatments that will prevent cancers from evading conventional drug treatments.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

THE BIGGER HOPE. “More generally, systems biology holds the promise of helping to decrease the time and costs of developing new drugs and also helping to provide more targeted and safe candidate drugs by leveraging pathway analysis.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

FRAGMENT FROM NATURE deals with a scant explored subject, namely biological time scales. With ranges of biological time from nanoseconds for some biochemical reactions to millennia for some types of evolution, and the likelihood that time scale shifts may be subject to some type of emergence, it is curious that we have so ignored this topic. View in LinkedIn

SPACE AND TIME, are the two variables that dominate physics. So with biology: dimensional scales and time scales are of considerable importance. The quantum scale is ruled by different forces than the classical scale. Time for a bacteria is on a different scale than for a human. View in LinkedIn

STARTING WITH TEASERS on a variety of different time perspectives. When we slip into a different time lens, we see the world completely differently. There are ancient beings on earth who appear to have this perspective, such as viruses, who seem at ease waiting millennia for the right time to animate. View in LinkedIn

WORLD POPULATION ANIMATION. Only when seen as a time lapse curve can you viscerally appreciate the data. “It took 200,000 years for our human population to reach 1 billion—and only 200 years to reach 7 billion.” One of the most important time lapse videos ever. https://youtu.be/PUwmA3Q0_OE View in LinkedIn

TIME LAPSE of airplanes and ships. The view in another time scale shows the phenomenal global interconnectivity, greatly belying our national separateness. https://youtu.be/FiZqn6fV-4Y View in LinkedIn

NINE ELEVEN. One World Trade Center 11 year time lapse. A big picture perspective on an emotionally charged blip in history. https://youtu.be/NbA89YbWoL8 View in LinkedIn