Month: September 2022

EXISTING GENES. "These studies provide support for the idea that the genetic machinery to regenerate a limb is available in humans, and that regeneration-competent animals have maintained access to reactivating these developmental programs." https://lnkd.in/d_NDPcr View in LinkedIn

LIMITED REGENERATION. "Many of the tissues of the adult limb have an inherent capacity to undergo a limited regenerative response to injury. Muscle regeneration is perhaps the best-studied example, and in this case, regeneration involves the proliferation and differentiation of a stem cell population (satellite cells) associated with mature muscle." http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn

LIMITED REPAIR TISSUES. "In addition, bone tissue has limited repair potential in that new bone is formed from mesenchymal stem cells located in the bone marrow to repair a break or fracture. Tendons and ligaments also undergo limited regenerative healing. Other tissues of the limb, such as the skin, are less successful in their response to injury and heal imperfectly." http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn

DEDIFFERENTIATION DEFINITION. "We propose to define dedifferentiation simply as the regression of a cell from a differentiated state to an embryonic state." http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn

INJURY GENES. "Associated with the injury response, a number of regeneration-specific genes will also be upregulated. A subset of these genes may be linked to the initiation of the dedifferentiation process, another subset of genes may be inhibitory for dedifferentiation, and a final subset may be completely unrelated." http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn

SUPER-FAST HEALING. "Urodele wound closure occurs incredibly fast; in young axolotls, an amputation wound is closed within 4 hr, and in the adult newt, wound closure is completed in less than 12 hr. By comparison to a similar-size mammalian wound, for example, an amputated mouse digit that takes multiple days to close, the speed of urodele wound closure is extraordinary." http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn

WOUND HEALING involves dedifferentiation. http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn

THE FUTURE. "Certainly, the tremendous successes we have witnessed in animal cloning demonstrate the feasibility of reactivating developmental programs in adult cells." http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn

RESTORATION DREAMS. "The general conclusion that a reduction in regenerative potential in humans is an example of a lost function can be viewed as a positive indicator for efforts aimed at inducing, or rather restoring, a regenerative response." http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn

REGENERATION IN MAN. "Progress in our understanding of the molecular basis of the regenerative response is moving rapidly, and the goal of eventually inducing a regenerative response in humans may lie in the not so distant future." http://onlinelibrary.wiley.com/doi/10.1002/ar.b.20082/full View in LinkedIn