Month: September 2022

DISPOSABLE SOMA. "It was considered as “a priori” assumption that bacteria have not separation between soma and germ-line, and therefore under the paradigm of disposable soma theory, that is the soma is the only biological entity that would undergo senescence (aging, the bacteria could not age." https://lnkd.in/d8UFqbd View in LinkedIn

TELOMERE HYPOTHESIS. "A current hypothesis gaining prominence proposes that activation of the enzyme telomerase is necessary for cells to become immortal, or capable of proliferating indefinitely. The theory suggests that almost all cancer cells must attain immortality for progression to malignant states and, hence, require activation of telomerase.” https://lnkd.in/efS2ct4 View in LinkedIn

PROFESSOR LEONARD HAYFLICK has probably done more for the biology of aging than anybody else. Excerpts from some of his papers will be quoted extensively in the coming sections. He is a contrarian with strong views. http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

THE HAYFLICK LIMIT. "Dr. Hayflick noticed that cells grown in cultures reproduce by dividing. They produce facsimiles of themselves (by a process known as mitosis) a finite number of times before the process stops for good and the cell dies. In addition, cells frozen during their lifetimes and later returned to an active state had a kind of cellular memory: The frozen cells picked up right where they left off. In other words, interrupting the cells' life span did nothing to lengthen it.” https://lnkd.in/eXXDjuG View in LinkedIn

LEONARD HAYFLICK "and his associates have vehemently condemned "anti-aging medicine" and criticized organizations such as the American Academy of Anti-Aging Medicine. Hayflick has written numerous articles criticizing both the feasibility and desirability of human life extension, which have provoked responses critical of his views.” https://lnkd.in/egWqSRn View in LinkedIn

HOUSEHOLD NAME. “Leonard Hayflick (born 20 May 1928 in Philadelphia, Pennsylvania), Ph.D., is an American anatomist. He is the Professor of Anatomy at the University of California, San Francisco, School of Medicine, and was Professor of Medical Microbiology at Stanford University School of Medicine. He is a past president of the Gerontological Society of America and was a founding member of the council of the National Institute on Aging (NIA).” https://en.m.wikipedia.org/wiki/Leonard_Hayflick View in LinkedIn

HAYFLICK "Developed the first normal human diploid fibroblast cell strains such as WI-38 and the technology for producing vaccines against polio and other human viral diseases" affecting over 2 million people. https://lnkd.in/dQMB4k7 View in LinkedIn

PREDICTION. “It is possible that the etiology of all age-associated diseases is in the molecular state that exists in old cells.” (Hayflick). http://science.howstuffworks.com/life/genetic/hayflick-limit.htm View in LinkedIn

HOW AND WHY WE AGE, Leonard Hayflick, forever the contrarian. "Hearts do not naturally get weaker with age; Regular exercise and a low-fat diet won't slow aging; Curing cancer would only add two years to the average sixty-five-year-old American life. Curing heart disease, however would add fourteen years; Only five percent of people over the age of sixty-five are in nursing homes; No human has lived--or probably can live--past 120 years." https://lnkd.in/eKPhKvH View in LinkedIn

CAUSE OF AGING. “It is possible that the etiology of all age-associated diseases is in the molecular state that exists in old cells or cells near the end of their lineage. I’ve been vocal about this for 40 years. And as a consequence of that you don’t make too many friends. But I am more interested in the truth than making friends.” (Hayflick). https://lnkd.in/dQMB4k7 View in LinkedIn