Month: September 2022

CANDIDATE LONGEVITY GENES. “The partners of known LAGs in the worm and human longevity networks may participate in the intricate pathways and complexes that regulate lifespan, and are therefore candidate longevity genes. Our primary analysis, 156 of these inactivations resulted in extended (101) or decreased (55) lifespan. We confirmed a subset (30 genes) of these phenotypes in rigorous longitudinal analyses.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

GENE SHORTLIST. “We longitudinally confirmed 11 positive regulators of lifespan; these genes decrease C. elegans longevity when inactivated post-developmentally. We confirm 30 new LAGs identified through network analysis of C. elegans and human candidates.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

SPONGE LONGEVITY GENE CLONED. "One gene, SDLAGL, was identified in the marine sponge Suberites domuncula whose deduced polypeptide showed high sequence similarity to the longevity assurance genes from other Metazoa." https://lnkd.in/ekmRrmm View in LinkedIn

CONSERVED CANDIDATE GENES. “A comparative genomics approach found longevity genes conserved between yeast Saccharomyces cerevisiae and nematode Caenorhabditis elegans. We hypothesised that these longevity genes influence variance in cognitive ability and age-related cognitive decline in humans.” https://lnkd.in/eswdkPD View in LinkedIn

TRANSCRIPTION FACTOR CANDIDATES. “FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In contrast to previous studies suggesting that DAF-16F plays a more prominent role in life span control than DAF-16A, isoform-specific daf-16/FoxO mutant phenotypes and whole transcriptome profiling revealed a predominant role for DAF-16A over DAF-16F in life span control, stress resistance, and target gene regulation.” https://lnkd.in/eP_v6ZE View in LinkedIn

CROSS-TAXA ANALYSIS. “Thanks to recent large-scale genome sequencing efforts, the genomes of multiple species have been sequenced and can be used for cross-species comparisons to study species divergence in longevity. By analyzing proteins under accelerated evolution in several mammalian lineages where maximum lifespan increased, we identified genes and processes that are candidate targets of selection when longevity evolves.” http://link.springer.com/article/10.1007/s11357-011-9361-y View in LinkedIn

METABOLISM AND LONGEVITY. “We found that processes such as lipid metabolism and cholesterol catabolism show such patterns of selection and suggest a link between the evolution of lipid metabolism, cholesterol catabolism, and the evolution of longevity. Lastly, we found evidence that the proteasome–ubiquitin system is under selection specific to lineages where longevity increased and suggest that its selection had a role in the evolution of longevity.” http://link.springer.com/article/10.1007/s11357-011-9361-y View in LinkedIn

MANY VARIABLES. “The identification of longevity-related genes does not explain the mechanisms of healthy aging and longevity rather pose questions on epigenetic contribution, gene regulation and the interactions with essential genomes, i.e. mitochondrial DNA and microbiota. To fully disentangle what appears to be an endless quest, all the components of the complexity of human longevity genetics are taken into account.” http://www.ingentaconnect.com/content/ben/cvp/2014/00000012/00000005/art00007 View in LinkedIn

LARGE AGING LINKAGE STUDY. “Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers of 11 European countries as part of the Genetics of Healthy Aging (GEHA) project.” https://lnkd.in/dT7y7Ze View in LinkedIn

CANDIDATE GENES EMERGE. “In the largest linkage scan thus far performed for human familial longevity, we confirm that the APOE locus is a longevity gene and that additional longevity loci may be identified at 14q11.2, 17q12-q22, and 19p13.3-p13.11. As the latter linkage results are not explained by common variants, we suggest that rare variants play an important role in human familial longevity.” (APOE is a class of fat metabolizing pathway proteins linked to Alzheimer’s). http://onlinelibrary.wiley.com/doi/10.1111/acel.12039/full View in LinkedIn