Month: September 2022

STEM CELLS FOR TISSUE DAMAGE. “Taking their cue from salamander regeneration, a team led by the University of New South Wales says that a stem cell therapy capable of regenerating any human tissue damaged by injury, disease, or aging could be available within a few years, thanks to an innovative new technique.” https://lnkd.in/djdqzys View in LinkedIn

MAKING MICE HEARTS YOUNGER. “In this study, we were able to show that a protein that circulates in the blood is related to this aging process, and if we gave older mice this protein, we could reverse the heart aging in a very short period of time,” Lee said. “We are very excited about it because it opens a new window on the most common form of heart failure.” https://lnkd.in/dSqtGre View in LinkedIn

REVERSING STEM CELL SENESCENCE."Researchers were able to turn back the molecular clock by infusing the blood stem cells of old mice with a longevity gene and rejuvenating the aged stem cells’ regenerative potential. “We already know that sirtuins regulate aging, but our study is really the first one demonstrating that sirtuins can reverse aging-associated degeneration. This opens the door to potential treatments for age-related degenerative diseases.” https://lnkd.in/dEjczux View in LinkedIn

SIROLIMUS, an anti-organ rejection drug, called "Rapamycin is shown to increase longevity by inhibiting the target of rapamycin kinase (TOR). Study systems including yeast, nematodes, flies, and mammals, have shown that reduction of TOR signaling will result in an increased life span." http://en.m.wikipedia.org/wiki/Life_extension View in LinkedIn

ANOTHER ANTI-AGING STRATEGY. "By tricking the cell into thinking it’s young again, with adequate amounts of NAD, aging can theoretically be reversed. “When we give the molecule, the cells think oxygen levels are normal and everything revs back up again." During aging, NAD drops 50%. http://healthland.time.com/2013/12/19/reversing-aging-not-as-crazy-as-you-think/ View in LinkedIn

VENTURE-BACKED EFFORT. “In his latest effort, Venter and backers announced the $70 million start of Human Longevity Inc. (HLI), a partnership with the University of California, San Diego, and other scientific organizations. "HLI is going to change the way medicine is practiced by helping to shift to a more preventive, genomic-based medicine model which we believe will lower healthcare costs. Our goal is not necessarily lengthening life, but extending a healthier, high performing, more productive life span. This is Celera on steroids and cocaine." Co-founders include Craig Venter, Ph.D., Robert Hariri, M.D., Ph.D., and Peter H. Diamandis, M.D. https://lnkd.in/dkR6ua5 View in LinkedIn

CAPITAL FUEL. “Human Longevity, Inc. raised more than $220 million. It has previously raised $80 million in its Series A offering which closed in Summer 2014. (2015). https://lnkd.in/dKgF-_9 View in LinkedIn

DARPA SEEKS LIFE EXTENSION. "The "Biochronicity" programme will find a way to understand and predict "temporal features of biological systems". After two years, DARPA hopes to move to Phase II, which aims to conduct Live Fire Tests. Should the research prove practicable, it could be used to put injured soldiers into effective suspended animation." https://lnkd.in/dsbyDDh View in LinkedIn

DARPA SEEKS CELLULAR CLOCK MECHANISM. "It could also make it possible to put astronauts into hibernation before firing them at Mars or other planets, or even - perhaps - to offer hugely extended human lifespan: Additionally, a greater understanding of molecular oscillators and the evolution of biological clocks will lead to fundamental advancements in developmental science, drug development, aging, and cell death." http://www.theregister.co.uk/2011/07/19/darpa_sleep_research/ View in LinkedIn

CHANGING EVOLUTION. “Darpa is looking to re-write the laws of evolution to the military’s advantage, creating “synthetic organisms” that can live forever — or can be killed with the flick of a molecular switch. As part of its budget for the next year, Darpa is investing $6 million into a project called BioDesign, with the goal of eliminating “the randomness of natural evolutionary advancement.” https://lnkd.in/dr8DZSH View in LinkedIn