Month: September 2022

ADAPTIVE PLASTICITY OF SOMA. "This very frailty, this permanent reprieve and the interdependence they generate between our cells, are one of the bases of our perennity and our plasticity, allowing our bodies to build themselves, to constantly reconstruct, and to adapt to ever changing environments." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

SOCIAL CONNECTIVITY AND DEATH. "But the permanent coupling of each cell fate to the nature of the interactions it can establish with the collectivity to which it belongs, represents only one dimension of the 'social control' of cell survival and cell death." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

INTERNAL AND EXTERNAL DEATH PROMPTS. "At another level, each individual cell may be considered as a complex entity, a 'society' by itself, a mingling of heterogeneous organelles and components that behaves as a whole. And self-destruction can occur not only as a response to signals originating from the outside environment of the cell, but also from its inside environment." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

"CELL SUICIDE plays an essential role in the maintenance of the genetic identity and the integrity of the body, by inducing the rapid elimination of altered cells." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

DEATH AND GENERATION OF COMPLEXITY. "Programmed cell death plays a central role in development, participating in particular in morphogenesis (the sculpting of the form of embryos), in sexual differentiation, and in the epigenetic self-organization processes that allow the emergence of the two most complex regulatory organs of our body, the immune system and the nervous system." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

DEATH FOR ADULT HOMEOSTASIS. "Programmed cell death is also crucial in the adult, by allowing tissue homeostasis, elimination of damaged or abnormal cells, and defense against infections. It may also play an important but poorly explored physiological role in metabolism, by allowing energy recycling through the ingestion of dying cells by neighboring cells." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

CONSERVED. "Programmed cell death has been found to operate in all multicellular animals studied so far, including cnidaria, nematodes, insects, amphibians, birds and mammals. The evolutionary conservation of programmed cell death in the animal kingdom does not only involve its existence and role, but extends to some central aspects of its genetic control, and to important aspects of its most frequent phenotype, apoptosis." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

EXTERNAL SIGNALS. "In all cases that have been studied to date, programmed cell death is regulated by signals provided by other cells, either in the form of cell-lineage information, of soluble mediators, or of cell-to-cell contacts." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

TRIGGERS. "Programmed cell death induction may depend essentially on cell-lineage information, such as in the nematode Caenorhabditis elegans, on the activation of gene transcription, such as in the fruitfly Drosophila melanogaster, or, in a more stochastic way, on a combination of cell-lineage information, intercellular signaling, transcription factor activation and cytoplasmic second messengers, such as in mammals." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

FAMILIES OF GENES. "During the last nine years, homologues of genes involved in the regulation of programmed cell death in Caenorhabditis elegans have been identified in sponge, in Hydra vulgaris, in the fruitfly Drosophila melanogaster, in zebrafish, in mice and in humans." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn