Month: September 2022

CONSERVATION AND DIVERSITY. "As frequently occurs during evolution, however, this striking conservation in both sequences and functional properties has been associated with a great level of diversification." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

SELF-DESTRUCTION KEY TO EVOLUTION. ""The observation that plant cells share with animal cells the capacity to self-destruct in response to environmental changes and cell signaling has reinforced the idea that programmed cell death may have played an essential role in the development, survival and evolution of most, if not all, multicellular organisms." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

QUESTIONS. "The first multicellular animals and plants belonging to the eukaryote terminal crown group are believed to have appeared around 0.7 to more than one billion years ago. Were they the first living beings whose cells were endowed with the capacity to self-destruct? Were effectors of cell suicide already present and operational in the first multicellular animals and plants, or were they selected later from other ancestral signaling pathways? When did the capacity to self-destruct initially appear?" http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

SOCIAL REGULATION OF DEATH. ""The emergence of a genetic program allowing a social form of regulation of cell survival and cell death, through a process of 'altruistic' cell suicide, has been considered as one of the solutions that evolution has provided to the specific problem of multicellular bodies and attributed to the selective pressure that applied to the emergence of multicellularity, including a process of kin selection between cells sharing the same genome and condemned to live together." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

PHENOTYPE TARGET OF SELECTION. "Natural selection does not act directly on genes, but on the phenotypes they allow the cell that encodes them to achieve." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

MUTATION AND PHENOTYPE. "Genetic mutation leads to genetic diversification, and hence to phenotypic diversity." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

DEATH OF WEAK PHENOTYPES. "Natural selection sanctioned by death is a process of competition between phenotypes whereby genomes allowing for poorly adapted phenotypes do not get transmitted into the next generation, while genomes that allow fitter phenotypes become selected." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

GRAVE OR CRADLE. "Simply put, the phenotype represents either the grave of a given genome or its vehicle into the next generation." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

KILLING GENOMES. "Genetically regulated programmed cell death is a phenotype that is characterized by the rapid disappearance of the cell that is expressing it. In other words, genes that encode effectors of programmed cell death can be viewed as allowing a phenotype that is the grave of the genome that expresses them." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

SELECTION OF DEATH GENES. "Any mutant gene that might have emerged randomly and allowed regulated cell suicide, would have rapidly and obligatorily led to the counter-selection of the individual cell expressing such a mutant gene." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn