Month: September 2022

WIDELY CONSERVED. “Programmed cell death has been found to operate in all multicellular animals studied so far, including cnidaria, nematodes, insects, amphibians, birds and mammals. The evolutionary conservation of programmed cell death in the animal kingdom does not only involve its existence and role, but extends to some central aspects of its genetic control, and to important aspects of its most frequent phenotype, apoptosis." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

REGULATED DEATH. “In all cases that have been studied to date, programmed cell death is regulated by signals provided by other cells, either in the form of cell-lineage information, of soluble mediators, or of cell-to-cell contacts." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

DEATH FOR INCREASED FITNESS. "Programmed cell death (PCD) serves the interests of multicellular organisms in many ways. Because it increases the fitness of the organism, there is no mystery about the function of PCD in plants and animals." View in LinkedIn

REF FOR LAST POST." "Are Internal, Death-Promoting Mechanisms Ever Adaptive?" "John W Pepper1,2, Deborah E Shelton1, Armin Rashidi1 and Pierre M Durand1,3* View in LinkedIn

REF FOR TODAY’S POST. Are Internal, Death-Promoting Mechanisms Ever Adaptive?" "John W Pepper, Deborah E Shelton, Armin Rashidi and Pierre M Durand" "Journal of Phylogenetics & Evolutionary Biology View in LinkedIn

PROGRAMMED CELL DEATH "seems paradoxical, however, in cases where the single cell is the entire organism. In some species ambiguity arises as to whether cells are organisms or parts of organisms." View in LinkedIn

INTERNAL REAPER. "There is substantial evidence that cell death is often internally controlled and regulated in unicellular organisms." View in LinkedIn

CONSERVED AND ADAPTED. "The ancient and deeply conserved genetic and molecular pathways that cause cell death indicate that death-promoting mechanisms show less variability than would be expected for unavoidable or maladaptive death.” View in LinkedIn

PROKARYOTIC DEATH GENES. "The caspase gene super-family is involved in cell death in both prokaryotes and eukaryotes, suggesting that it is functionally conserved and arose early in prokaryote evolution." View in LinkedIn

AUTOPHAGY. "Potential convergence on the autophagic death phenotype also indicates that death-promoting mechanisms may have been selected for in unicells. The autophagic death phenotype and elements of its molecular pathway have been described in evolutionarily diverse, unrelated unicellular eukaryotes such as the stramenopiles, the kinetoplastids and the social amoebae." View in LinkedIn