Month: September 2022

REDUCTIONISM. "During the latter half of the 20th century, biology was dominated by reductionist approaches that successfully generated information about individual cellular components and their functions. Over the past decade, this process has been greatly accelerated by the emergence of genomics." https://scholar.google.es/scholar?q=in+silico+chemistry+of+emergence+of+life&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwj40qHQlMXLAhWCnRoKHRtCAjkQgQMICDAA View in LinkedIn

INTEGRATIVE APPROACHES. "It has become generally accepted that the integrative analysis of the function of multiple gene products has become a critical issue for the future development of biology. It is thus likely that over the coming years and decades, the biological sciences will be increasingly focused on the systems properties of cellular and tissue functions. These are the properties that arise from the whole, and represent “real” biological properties." https://scholar.google.es/scholar?q=in+silico+chemistry+of+emergence+of+life&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwj40qHQlMXLAhWCnRoKHRtCAjkQgQMICDAA View in LinkedIn

EMERGENT PROPERTIES. "These properties are sometimes referred to as “emergent” properties because they emerge from the whole and are not properties of the individual parts." https://scholar.google.es/scholar?q=in+silico+chemistry+of+emergence+of+life&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwj40qHQlMXLAhWCnRoKHRtCAjkQgQMICDAA View in LinkedIn

THE BIG GAP. "While the last century brought an exquisite understanding of the molecular basis of life, very little is known about the detailed chemical mechanisms that afforded the emergence of life on early earth." https://lnkd.in/dWndif7 View in LinkedIn

"SELF-REPLICATION occurs when an informational molecule (such as a nucleic acid) directs the spontaneous synthesis of a replica of itself. Mechanisms for self-replication can be autocatalytic, where a molecule acts as a template to make a direct copy of itself, or cross-catalytic, where two or more molecules of different informational content amplify one another." http://link.springer.com/referenceworkentry/10.1007%2F978-3-642-11274-4_1423 View in LinkedIn

ABIOGENESIS "is the natural process of life arising from non-living matter, such as simple organic compounds." Considered to occur during the origin of life on our planet (or elsewhere). https://lnkd.in/dcd-YRj View in LinkedIn

LIFE IN VENTS. “While features of self-organization and self-replication are often considered the hallmark of living systems, there are many instances of abiotic molecules exhibiting such characteristics under proper conditions. Stan Palasek showed that self-assembly of ribonucleic acid (RNA) molecules can occur spontaneously due to physical factors in hydrothermal vents." https://lnkd.in/dcd-YRj View in LinkedIn

MOLECULAR REPLICATORS. "Autocatalysts are substances that catalyze the production of themselves and therefore are "molecular replicators." https://en.m.wikipedia.org/wiki/Abiogenesis View in LinkedIn

SUMMARY of self-replicating simple and complex molecules that make prions seem much more normal. Here are summaries of self-replicating systems including: hexadeoxynucleotides, RNA li gases, peptides, small molecules, ribozymes, micelles, prions and amyloid. https://lnkd.in/d6v_X9T View in LinkedIn

"THE RNA WORLD HYPOTHESIS describes an early Earth with self-replicating and catalytic RNA but no DNA or proteins. It is generally accepted that current life on Earth descends from an RNA world, although RNA-based life may not have been the first life to exist." https://en.m.wikipedia.org/wiki/Abiogenesis View in LinkedIn