Month: September 2022

"THE TWO EXCEPTIONS to the observation that major energy metabolic pathways are constrained are the calvin cycle and photosynthesis pathways. These pathways showed significant genetic constraint but no statistical support for developmental constraints most likely due to the difference in photosynthetic capacity between roots and shoots." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

GREATER PLASTICITY IN YOUNGER GENES. "In all instances, the younger tandem duplicated genes showed higher intraspecific gene expression variation than the average Arabidopsis gene. Surprisingly, the older segmental duplicates also showed evidence of elevated intraspecific gene expression variation albeit typically lower than for the tandem duplicates." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

FUNCTIONAL CONSTRAINTS. "The specific biological function of the gene as defined by metabolic pathway also modulated the level of intraspecific gene expression variation. The major energy metabolism and biosynthetic pathways showed decreased variation, suggesting that they are constrained in their ability to accumulate gene expression variation." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

PLASTICITY IN DEFENSE GENES. "In contrast, a major herbivory defense pathway showed significantly elevated intraspecific variation suggesting that it may be under pressure to maintain and/or generate diversity in response to fluctuating insect herbivory pressures." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

LOCI CONTROL POINTS. "Gene expression variation of segmental and tandem duplicated genes was controlled by a greater number of genetic loci, and these loci had larger effects on gene expression variation for tandem duplicated genes." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

PATHWAY CONSTRAINTS. "Gene participation in specific metabolic pathways predicted the level of intraspecific variation in gene expression, with major energy and amino acid pathways having relatively lower levels of gene expression variation. This suggests that these primary metabolism pathways are genetically constrained." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

PLASTICITY FOR CHANGES. "In contrast, a major secondary metabolite pathway in Arabidopsis showed a significantly increased level of gene duplication and intraspecific gene expression variation, suggesting that this pathway may be structured to cope with fluctuating selection in the wild. As such, the influence of gene duplication on intraspecific gene expression variation partly depends upon the biological function of the gene involved." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

NEW GENE FORMATION. "Within the aliphatic glucosinolate biosynthetic pathway, increased transcript variation across naturally variable Arabidopsis accessions is associated with tandemly duplicated enzymes. This tempts the conclusion that these gene families are undergoing genetic sub-functionalization. However, biochemical analysis of these gene families shows that they have already undergone neo-functionalization, creating new biosynthetic activities in the duplicate enzymes." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

DRAMATIC OUTLIER. "Pathway level transcript variation for the aliphatic glucosinolate biosynthetic pathway was a dramatic outlier in both accession datasets." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn

OUTLIER FOR DIVERSITY. "Gene expression variation across the different accessions was distributed such that the enzymatic steps responsible for determining the final chemical structure had elevated gene expression variation, suggesting that variation in this pathway may be selected to generate structural diversity." http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001838 View in LinkedIn