Month: September 2022

ABUNDANCE TAP. "Together with nonsense-mediated decay (NMD), at least 25% of all alternative exons are predicted to regulate transcript abundance." http://www.sciencedirect.com/science/article/pii/S037811190400650X View in LinkedIn

EXON SELECTIONS. "Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins. In this process, particular exons of a gene may be included within or excluded from the final, processed messenger RNA (mRNA) produced from that gene." https://en.m.wikipedia.org/wiki/Alternative_splicing View in LinkedIn

PROTEIN AMPLIFICATION. "The proteins translated from alternatively spliced mRNAs will contain differences in their amino acid sequence and, often, in their biological functions. Notably, alternative splicing allows the human genome to direct the synthesis of many more proteins than would be expected from its 20,000 protein-coding genes." https://en.m.wikipedia.org/wiki/Alternative_splicing View in LinkedIn

CRUCIAL ROLES. "Most human genes are alternatively spliced, allowing the selection of different combinations of exons to produce multiple distinct mRNAs and proteins. Many types of alternative splicing are known to play crucial roles in biological processes including cell fate determination, tumor metabolism, and apoptosis." http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001229 View in LinkedIn

"THE SPLIT STRUCTURE of eukaryotic genes impacts gene expression and evolution in diverse ways. Most directly, the presence of introns enables multiple distinct mRNA and protein products to be produced from the same gene locus through alternative splicing, which is often regulated between tissues or developmental stages." http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001229 View in LinkedIn

EXON SKIPPING. "Alternative inclusion or exclusion of exons—“exon skipping”—can generate protein isoforms with distinct subcellular localization, enzymatic activity or allosteric regulation, and differing, even opposing, biological function." http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001229 View in LinkedIn