Month: September 2022

DOMINANT HUMAN CELLS. "We could see the human cells taking over the whole space,” says Goldman. “It seemed like the mouse counterparts were fleeing to the margins. Human astrocytes are 10 to 20 times the size of mouse astrocytes and carry 100 times as many tendrils. This means they can coordinate all the neural signals in an area far more adeptly than mouse astrocytes can. “It’s like ramping up the power of your computer." https://lnkd.in/d2TkhaZ View in LinkedIn

THE UNKNOWN. "Reconstituting human glial cells or neurons in animal brains could eventually impart complex cognitive behaviors, self-awareness, and/or other humanlike personality characteristics to these chimeras." https://lnkd.in/dTarAZs View in LinkedIn

REPAIR HOPES. "We characterize the survival, migration, and differentiation of human neurospheres derived from CNS stem cells transplanted into the ischemic cortex of rats...transplanted human CNS (hCNS)-derived neurospheres survived robustly in naive and ischemic brains." https://lnkd.in/dUpGPqf View in LinkedIn

FUTURE PATH. "Fetal brain tissue transplants have been shown to produce some recovery in animal models of stroke." http://www.pnas.org/content/101/32/11839.full View in LinkedIn

EXPANDED ENQUIRY. "More recently, a host of cell types have been tested in stroke models, including human bone marrow cells, human umbilical cord blood cells, rat trophic factor-secreting kidney cells, and immortalized cell lines such as the human neuron-like NT2N (hNT) cells and MHP36, an embryonic murine immortalized neuroepithelial cell line." http://www.pnas.org/content/101/32/11839.full View in LinkedIn

LEAP FORWARD. "The field of stem-cell biology has been catapulted forward by the startling development of reprogramming technology. The ability to restore pluripotency to somatic cells through the ectopic co-expression of reprogramming factors has created powerful new opportunities for modelling human diseases and offers hope for personalized regenerative cell therapies." https://lnkd.in/dMmyqzS View in LinkedIn

PROMISING RESULTS. "Studies in animal models of Parkinson's disease (PD) and Huntington's disease (HD) show that transplanted human neural precursor cells survive and differentiate into neurons and glia." http://www.pnas.org/content/101/32/11839.full View in LinkedIn

BROAD PROOF-OF-CONCEPT. "Transplanted interneurons have been shown to modify disease phenotypes in several rodent models of neurologic and psychiatric disorders, including epilepsy, chronic pain, Parkinson’s disease, schizophrenia, and anxiety." https://lnkd.in/dfXR-Jt View in LinkedIn