Month: September 2022

Very early evidence of the use of glasses (Lyon Art Museum). View in LinkedIn

QUESTION. “Can the circadian clock feedback and regulate properties of tumorigenesis? If so, what are these circadian cues that modulate cancer progression systemically?” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CLOCKS AND CANCER. “These findings suggest a crosstalk between the circadian clock and cancer cells through the tumor-derived macroenvironment and underscore the ability of canonical and noncanonical clock components to regulate a metastatic secretome.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

UNKNOWNS. “Further investigation is needed to better understand how the clock controls metastasis in different cancer types and how this tumor-dependent secretome may differ because of disease profile.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

RECYCLED WASTES. “Importantly, evidence also suggests that tumor-derived waste can be repurposed and subsequently utilized as fuel for tumors.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

METABOLIC SWITCHING. “Clinical and laboratory studies have provided evidence that NSCLC exhibits metabolic heterogeneity in fuel utilization and, while glucose oxidation is metabolically imperative, lactate can also be used as a carbon source.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ALTERNATE PATHWAY. “A similar example exists with nitrogen repurposing of ammonia waste that was reported to be recycled into central amino acid metabolism through the enzymatic activity of glutamate dehydrogenase in breast cancer cells.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

FEEDING A GROWING CITY. “These studies suggest a mechanism by which the tumor-derived macroenvironment can be recycled as alternative fuel sources for rapidly proliferating cells.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

THESIS. “Given the fundamental role of the circadian clock in regulating metabolism, including pathways involved in carbohydrate, amino acid, and fatty acid and lipid metabolism, it is plausible that the circadian clock may be involved in regulating these processes in the context of cancer.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

RECYCLING CLOCK. “Also, it is possible that tumor-dependent metabolic waste may be secreted in a temporal manner, suggesting peak times of day whereby these metabolic pathways could be targeted pharmacologically.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn