Month: September 2022

TREATMENT ISSUE. “The multiple connections discussed here between clock disruption and cancer beg the question of whether circadian therapeutic intervention (such as time of day) should be considered for treatment of cancer.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

RX TIMING. “This so-called ‘chronotherapy’ has been recently reviewed in depth, and evidence strongly supports the idea that metabolic and xenobiotic detoxification enzymes exhibit temporal peaks in activity and thus should be pharmacologically targeted based on optimal time of day.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CORRELATION. “The complex network of communication between the circadian clock and tumorigenesis is only beginning to be unraveled (Fig. 3). At the foundation is strong epidemiological evidence that implicates circadian disruption with cancer.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

SO ENDS this second and last weekend on an article about cancer and the cellular clock. Since circadian rhythms control a great number of cellular and behavioral events, dysfunctional clocks will inevitably have a plethora of effects, and contributing to initiating oncogenesis is no surprise. However, the evidence presented here and elsewhere show this dysfunction at a molecular and genetic level of granularity. https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

MIS-EXAPTATION. “The possible functional and genetic links between schizophrenia and creativity have been pointed out. Thus, in some cases creativity may reflect not so much the functioning of the brain but rather its borderline dysfunction hence when things go a little wrong, that something new is experienced.” (Extraordinary article). https://lnkd.in/dJ8dUGRd View in LinkedIn

STUNNING WOOD CARVING. Alegria, 2021, Mahogany, 295 x 175 x 146 cm, in In Villa del Arte art gallery, Barcelona. View in LinkedIn

FIRST ATOM IN THE UNIVERSE. “The word proton is Greek for "first", and this name was given to the hydrogen nucleus by Ernest Rutherford in 1920.” https://en.m.wikipedia.org/wiki/Proton View in LinkedIn

“PROTONS, together with electrically neutral particles called neutrons, make up all atomic nuclei except for the hydrogen nucleus (which consists of a single proton). Every nucleus of a given chemical element has the same number of protons. This number defines the atomic number of an element and determines the position of the element in the periodic table.”" " https://lnkd.in/e9rkP5x5 View in LinkedIn

PARTS OF PROTONS. “Protons are composite particles composed of three valence quarks: two up quarks of charge +2/3 e and one down quark of charge −1/3 e. The rest masses of quarks contribute only about 1% of a proton's mass. The remainder of a proton's mass is due to quantum chromodynamics binding energy, which includes the kinetic energy of the quarks and the energy of the gluon fields that bind the quarks together.” https://en.m.wikipedia.org/wiki/Proton View in LinkedIn

HIGH ENERGY PROTONS. “Free protons occur occasionally on Earth: thunderstorms can produce protons with energies of up to several tens of MeV.” https://en.m.wikipedia.org/wiki/Proton View in LinkedIn