Month: September 2022

SIGNIFICANT GENETIC COMMITMENT. "A significant portion of a bacterial genome (4%–10%) and proteome (20% or more) can be influenced by quorum signaling, which suggests that quorum sensing is a mechanism used by pathogenic bacteria not only to modulate virulence factor production but also to adapt to the metabolic demands of living in communities." http://cid.oxfordjournals.org/content/47/8/1070.long View in LinkedIn

QS CONTROLLED POST-HARVEST OROCESSES. "Er. carotovora causes the post-harvest soft rotting of many vegetable crops including potato, carrot and green pepper. The virulence of this plant pathogen depends on the synthesis and secretion of a number of exoenzymes including pectinases, cellulases and proteases. Expression of the genes coding for these plant cell wall degrading enzymes is controlled by QS." http://mic.sgmjournals.org/content/153/12/3923.full View in LinkedIn

DIVERSE QUORUM LANGUAGE. "Eukaryotes and prokaryotes have evolved diverse signalling mechanisms to detect and respond to each other. Although bacterial QS signal molecules have largely been considered as effectors of prokaryotic gene expression, they are bioactive molecules which can modify the behaviour of fungal, plant and animal cells." http://mic.sgmjournals.org/content/153/12/3923.full View in LinkedIn

QUORUM QUENCHING. "Over the last decade, many microbes capable of degrading QS molecules have been documented. In some cases, QS-bacteria could degrade their own autoinducers to terminate quorum-sensing activities. A limited number of QQ enzymes that interfere with bacterial QS molecules are known, although the general mechanisms of the QS system are well understood." https://lnkd.in/dEGPGEj View in LinkedIn

MEDICAL ANGLE OF QUORUM SENSING. "Quorum-quenching mechanisms are widely conserved in many prokaryotic and eukaryotic organisms. These naturally occurring quorum-quenching mechanisms appear to play important roles in microbe–microbe and pathogen–host interactions and have been used." https://lnkd.in/dp7sxG6 View in LinkedIn

POTENTIAL ANTIBIOTIC ALTERNATIVE. "With the ongoing emergence of antibiotic-resistant pathogens, there is a current need for development of alternative therapeutic strategies. Overall, the evidence suggests that QSI therapy may be efficacious against some, but not necessarily all, bacterial pathogens." https://lnkd.in/d8iYCZj View in LinkedIn

PROMISING APPROACH. "Why does quenching microbial quorum sensing hold promises in infection control? This novel strategy results from the realization that many single-celled microbial organisms, including bacterial and fungal pathogens, can communicate with each other and act collectively in the regulation of infection-related traits, including expression of virulence genes and production of biofilms." https://lnkd.in/dp7sxG6 View in LinkedIn

AVOIDING BACTERIAL RESISTANCE. "The quorum quenching therapeutic approach promises a lower risk of resistance development, since interference with virulence generally does not affect the growth and fitness of the bacteria and, hence, does not exert an associated selection pressure for drug-resistant strains." https://lnkd.in/dPSTiju View in LinkedIn

THE ECONOMIC BURDEN TRUMPS ALL. "The costs of treating tobacco-related illnesses and the resulting loss of productivity are leading economic arguments for tobacco control policies." https://lnkd.in/dKtA3ku View in LinkedIn

JUICY TAX REVENUES FROM BIG TOBACCO. "Tobacco has been taxed by state governments in the United States for decades. The cumulative revenue of US tobacco taxation exceeded $32 billion in 2010, creating a major source of income for government." http://en.m.wikipedia.org/wiki/Tobacco_politics View in LinkedIn