Month: September 2022

"HYPOTHESIS: gut bacteria control host appetites". Gut bacteria are involved in disease susceptibility including emotional disturbances and eating disorders, and gut bacteria pay a role in modulating satiety and pleasure." https://lnkd.in/eg9hzPv View in LinkedIn

DIET CRITICAL. The composition of the gut microbiota is largely determined by the types of foods eaten by the host and the amount of stress the host experiences. https://lnkd.in/eg9hzPv View in LinkedIn

MOOD AND BACTERIA. Hypothalamus-pituitary-adrenal axis is involved in many mood disorders. Recovery from these is correlated with increased numbers of the gut bacteria Baccilus Infantis. https://lnkd.in/eDFWAiD View in LinkedIn

REWARD SYSTEM CONTROL. Food choices by bacterial hosts are determined in part by a pleasure response; bacteria can modulate the human reward system in the brain to induce satiety. https://lnkd.in/eDFWAiD View in LinkedIn

DRAMATIC HIJACKING "of the host nervous system can occur through the microbiota sending short chain fatty acid signals to receptors on the vagus nerve, the seat of satiety, which connects the 100 million neurons in the gut to the brain." https://lnkd.in/eknVNSM View in LinkedIn

DRUG FACTORY. "The microbiota manufactures large quantities of neuroactive hormones including dopamine, serotonin, and norepinephrine which control pleasure centers in the brain." https://lnkd.in/eknVNSM View in LinkedIn

SMART BUGS. "Microbes produce a variety of neurochemicals that are exact analogs of mammalian hormones involved in mood and behavior. More than 50% of the dopamine and the vast majority of the body's serotonin have intestinal sources." https://lnkd.in/es44Vig View in LinkedIn

LANDMARK PAPER by Backhed et al. Genetically predisposed obese mice remained lean when raised in germ-free conditions without a microbiota. Fecal transplants of mouse feces from normal obese mice into these germ-free mice induced obesity. Inoculation of obese human feces into these germ-free mice produced the same outcome. https://lnkd.in/eGCSdvJ View in LinkedIn

BIOME AND OBESITY. Mice lacking the toll-like receptor TLR5 became obese and developed altered gut microbiota, hyperphagia, insulin resistance, and pro-inflammatory gene expression. Fecal pellets from these TLR5 knockout mice, when fed to wild type mice, induced the same phenotype. https://lnkd.in/eknVNSM View in LinkedIn

NEXT WEEKEND this fragment from nature theme will continue to explore the remarkable relationship between our gut Microbiome and our health and disease. This represents a massive and recent sea-change in our perspectives on health. View in LinkedIn