Month: September 2022

MANY ESSENTIAL OILS are made by organic synthesis from petrochemical precursors that have nothing to do with the original source, and many (most) are subject to scurrilous dilution and adulteration. Just check out truffle odor for instance. Never again. https://lnkd.in/euiVBnE View in LinkedIn

AUTHENTICITY assessments of food flavors and essential oils has spawned a significant literature. https://lnkd.in/e7dadSh View in LinkedIn

FLAVOR AND AROMA CHIRALITY. Three factors are true in gustation. "High similarity of aromas between different compounds with very dissimilar chemical structures; differing character of aroma between molecules of chemical compounds with very similar structures; the phenomenon of isomerism, occurring only in organic chemistry." https://lnkd.in/enRqV7d View in LinkedIn

ENANTIOMERS are opposite chiral pairs, one left- and the other right-handed. "The most surprising phenomena in the perception of smell are connected with optical isomerism...chiral differentiation was also considered one of the primary principles of smell perception...enantiomers may differ in aroma." https://lnkd.in/enRqV7d View in LinkedIn

MOLECULAR FLEXIBILITY. "An examination of a very large number of enantiomer pairs...shows a general rule: the members of an enantiomer pair will smell alike when the molecules are rigid, and will smell different when they are flexible." https://lnkd.in/eenjdnB View in LinkedIn

"20 MILLION CHEMICAL COMPOUNDS are known and a number of them are the so-called isomers. Isomers in chemistry are compounds with identical molecular formulas but differing in the nature of the sequence of the bonding of their atoms in space." https://lnkd.in/ef9kgYu View in LinkedIn

PHARMA RACEMATES. "About 25% of common drugs are racemates, i.e., mixtures of their optical or spatial isomers (stereoisomers or enantiomers). The currently available evidence suggests that for the enantiomers of many chiral drugs there are clear functional differences between the constituent enantiomers and the racemate." https://lnkd.in/ef9kgYu View in LinkedIn

DRUG PROPERTIES. "Pharmacological and toxicological effects can coexist in the same enantiomer or both." https://lnkd.in/eSukgNj View in LinkedIn

"DRUG CHIRALITY is critical for therapeutic potency and efficacy, and there are over 2,500 chiral drugs. For example, only one form of dopamine is effective in treating Parkinson's disease, the other causes granulocytopenia. Only one form of thalidomide alleviates morning sickness, while the other form causes birth defects." https://lnkd.in/eqzkdcz View in LinkedIn

SEPRACOR, now known as Sunovion Pharmaceuticals, built a brilliant business by identifying and patenting the more potent isomers in racemic drugs, and those with less side effects. https://lnkd.in/eT77Pdx View in LinkedIn