Month: September 2022

TRPA1 SUPERFAMILY. "TRPs are cation-selective channels that exhibit varying degrees of calcium permeability and respond to a wide range of stimuli (eg, temperature, mechanical, osmolarity, chemical). A subset of TRP channels is activated by different temperatures (eg, TRPV1-4, TRPM8, and TRPA1)." https://lnkd.in/ey47aVM View in LinkedIn

TRPA1 SUPERFAMILY. "TRPV1 and TRPV2 are activated by heat in the noxious range (>42°C and >52°C, respectively), whereas TRPA1 is reported to be activated by noxious cold (

SUPERFAMILY. "A class of ion channels that belongs to the transient receptor potential (TRP) superfamily and is present in specialized neurons that project to the skin has evolved as temperature detectors." https://lnkd.in/eZQCjnY View in LinkedIn

SUPERFAMILY. "These channels are classified into subfamilies, namely canonical (TRPC), melastatin (TRPM), ankyrin (TRPA), and vanilloid (TRPV). Some of these channels are activated by heat (TRPM2/4/5, TRPV1-4), while others by cold (TRPA1, TRPC5, and TRPM8)." https://lnkd.in/eZQCjnY View in LinkedIn

STRUCTURAL RELATIVES. "Transient receptor potential (TRP) channels are diverse six-transmembrane domain (6-TM) cation channels that are related to, and share, the transmembrane topology and functional domain structure of the tetrameric voltage-gated ion channels." https://lnkd.in/ecaVp5Q View in LinkedIn

TRP FAMILY. "Several dozen TRP channels have been identified and are classified into six subfamilies, including the TRP ankyrin family (TRPA), with varying degrees of sequence similarity and permeability to cations. TRPA1 is the only member of the ankyrin subfamily so far identified in mammals, and it contains at least 14 ankyrin repeats in the N-terminal intracellular domain." https://lnkd.in/ecaVp5Q View in LinkedIn

VARIOUS STIMULI. "A truly polymodal ion channel, TRPA1 is activated by various stimuli, including electrophilic chemicals, oxygen, temperature, and mechanical force, yet the molecular mechanism of TRPA1 gating remains obscure." https://lnkd.in/erPHnzY View in LinkedIn

WASABI RECEPTOR is yet another name for TRPA1, see this nice 3D reconstruction of the molecule. https://lnkd.in/ePnxtdx View in LinkedIn

MULTI-TASKING. "TRPs are multitasking proteins, and second, many functions and modes of activation of these channels are evolutionarily conserved, including some that were formerly thought to be unique to invertebrates, such as phototransduction." https://lnkd.in/ee5Y9gz View in LinkedIn

EXTRAORDINARY MULTIFUNCTIONALITY. "TRPA1 has become one of the most intensively studied ion channels. Its function has been linked to regulation of heat and cold perception, mechanosensitivity, hearing, inflammation, pain, circadian rhythms, chemoreception, and other processes." https://lnkd.in/erPHnzY View in LinkedIn