Month: September 2022

CENTER OF SYMMETRY PATHWAY. "ThermoTRPs share a common organization. They are tetramers where the permeation pathway is located in the center of symmetry of the channel. ThermoTRP are activated by different agonist obtained from different plants." https://lnkd.in/eZQCjnY View in LinkedIn

"ACTIVATION in temperature-sensitive TRP channels is characterized by very large enthalpy changes that are compensated by similarly large entropy changes. For example, enthalpy changes of about 100 kcal/mol, 200 kcal/mol, and 60 kcal/mol are involved in the opening of TRPV1, TRPV2, and TRPM8, respectively." https://lnkd.in/eZQCjnY View in LinkedIn

MOLECULAR MAPPING. "The molecular determinants of temperature sensing in TRPV1 have been located in the N terminal domain in the pore turret, in the outer pore region, and in the C terminal. TRPV1 and TRPV2... are heat receptors with different temperature thresholds and share an amino acid identity of about 70%." https://lnkd.in/eZQCjnY View in LinkedIn

CAPSAICIN LINK. "The capsaicin- and heat-activated non-selective cation channel TRPV1 exhibits robust temperature activation above 42°C in heterologous systems and primary neurons...TRPV1-deficient mice show complete loss of capsaicin sensitivity and significant reduction in the detection of noxious (≥50°C) heat stimuli and/or thermal hyperalgesia." Similarly, birds are oblivious to capsaicin. https://lnkd.in/eFfEp_R View in LinkedIn

MANY ACTIVATORS. "TRPA1 is activated by a variety of chemical compounds, such as allyl isothiocyanate in mustard oil (MO), allicin in garlic and onion, and synthetic drugs such as clotrimazole, chlorpromazine, and clioquinol." https://lnkd.in/ecaVp5Q View in LinkedIn

MANY ACTIVATORS. "TRPA1 can also be activated by endogenous metabolic products and oxidative stress-derived substances and sensitized through G protein-coupled receptors (GPCRs), cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), and protease activated receptor 2 (PAR2) signaling pathways." https://lnkd.in/ecaVp5Q View in LinkedIn

SENTINEL MOLECULE. "The non-selective cation channel TRPA1...is perhaps the most versatile of all polymodal sensory ion channels. Different TRPA1 orthologues were reported to mediate the detection of cold, heat and noxious chemicals, such as allyl isothiocyanate (AITC), the pungent agent from wasabi and other mustard plants." https://lnkd.in/eFfEp_R View in LinkedIn

METABOLIC ROLE. "Since many TRP channels are functionally implicated in sensory systems, it is thus not surprising to discover their direct (or indirect) modulatory role in the context of metabolic regulation." https://lnkd.in/ekDF8xf View in LinkedIn

THERMOREGULATION. "TRP channels are expressed in thermoregulatory effector organs, such as adipose tissue, muscle, vasculature and gastrointestinal tract, thereby potentially modulating the metabolic status." https://lnkd.in/ekDF8xf View in LinkedIn

EXTERNAL AND INTERNAL ALARM. "The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug metabolism. These include a broad class of electrophiles that activate the channel through covalent protein modification." https://lnkd.in/evaGrBq View in LinkedIn