Month: September 2022

NOT A STORED FUEL. "ATP is an energy-coupling agent and not a fuel. It is not a storehouse of energy set aside for some future need. Rather it is produced by one set of reactions and is almost immediately consumed by another. Energy metabolism is therefore mostly self-regulating." https://lnkd.in/eN5s-r4 View in LinkedIn

100 ATP PER SECOND. "ATP synthesis occurs at a maximal rate of the order of 100 s−1," in a single ATP synthase, each twirl of the motor is driven by 9 H(+) ions. This motor can spin at up to 9,000 RPM. http://www.sciencedirect.com/science/article/pii/S0005272802001858 View in LinkedIn

VIRUSES CONSUME HOST ATP. "The concentration of ATP is reduced in HCV-infected cells...These results suggest that ATP is actively consumed during viral replication in HCV replicon cells, leading to decreased levels of ATP in the cytoplasm." (Why viral infections leave you without energy). https://lnkd.in/eXVs6py View in LinkedIn

SOME ANCIENT microorganisms have learned to borrow their ATP. "E. cuniculi also uses these proteins to steal ATP from its eukaryotic host to sustain its lifestyle as an obligate intracellular parasite. Here we show that, consistent with this hypothesis, all four E. cuniculi transporters can transport ATP, and three of them are expressed on the surface of the parasite when it is living inside host cells." https://lnkd.in/eA9SjDZ View in LinkedIn

ATP GENERATION is a just-in-time manufacturing process that does not have large storage needs. ATP turnover is very rapid, and equally production can ramp up very swiftly to meet the cellular energy needs. http://www.sciencedirect.com/science/article/pii/S0005272802001858 View in LinkedIn

"APOPTOSIS and necrosis would be two extremes of a continuum of possible types of cell demise, whose shape and implications for the neighboring tissue would be decided by the availability of ATP, and likely by additional factors in the dying cell and in scavenger cells. This would explain the frequent coexistence of both types of cell death in pathological situations...where individual cell death within the tissue would be decided by the energy supply." https://lnkd.in/e3cRBYE View in LinkedIn

COEXISTENCE. "This would explain the frequent coexistence of both types of cell death in pathological situations...where individual cell death within the tissue would be decided by the energy supply." https://lnkd.in/e3cRBYE View in LinkedIn

LIMBO. "The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt increase in the permeability of the inner mitochondrial membrane to low molecular weight solutes. Widespread MPT has catastrophic consequences for the cell, de facto marking the boundary between cellular life and death." https://lnkd.in/eyXYjxQ View in LinkedIn

MITOCHONDRIAL PERMEABILITY TRANSITION results "in the structural and functional collapse of mitochondria, an event that commits cells to suicide via regulated necrosis or apoptosis." https://lnkd.in/eyXYjxQ View in LinkedIn

CELLULAR SUICIDE. "Apoptosis, a form of programmed cell death (PCD), is a genetically regulated active physiological process of cell suicide that causes cell deletion without inflammation, scarring, or release of cellular contents. Mitochondria of living cells play a pivotal role in controlling life and death." https://lnkd.in/eUWbyuT View in LinkedIn