linkedin post 2016-01-07 09:32:24

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"THE PRION ISOFORM is resistant to being degraded by cellular enzymes, so the newly-formed prions accumulate in the central nervous system. They then form aggregates, and these clumps of prions continue to increase in number. The aggregates in the brain tissue are called "amyloid plaques." http://www.strangehorizons.com/2004/20040216/killer.shtml View in LinkedIn
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linkedin post 2016-01-07 09:35:49

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CROSS-SPECIES PRION INFECTIVITY. "CJD from humans can infect laboratory rodents. BSE from cattle has been used to infect macaques. And, in 1996, clinicians in the United Kingdom described new variant CJD (nvCJD), a prion disease in humans that was believed to be caused by eating beef from BSE-infected cattle." http://www.strangehorizons.com/2004/20040216/killer.shtml View in LinkedIn
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linkedin post 2016-01-07 09:39:25

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NO TREATMENT. "Prion strains differ, but they do have one thing in common: they're incurable. The prion plaques can't be removed from the brain without killing the patient. Prions cannot be destroyed by antibiotics, chemotherapy, or anti-viral medications. So far, no treatment has been shown to cure a prion-infected animal or human." http://www.strangehorizons.com/2004/20040216/killer.shtml View in LinkedIn
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linkedin post 2016-01-08 06:38:38

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THE PRION HYPOTHESIS instead "claims that there is a source of information within protein molecules that contributes to their biological function, and that this information can be passed on to other molecules. But the protein molecules are still manufactured according to the instructions contained in nucleic acid. The additional information source is the conformation or shape of the protein molecule." https://lnkd.in/e4dnA_x View in LinkedIn
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linkedin post 2016-01-08 06:46:58

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PRIONS LACK DNA AND RNA. "A prion in the Scrapie form (PrPSc) is an infectious agent composed of protein in a misfolded form. This is the central idea of the Prion Hypothesis, which remains debated. This would be in contrast to all other known infectious agents (virus/bacteria/fungus/parasite)—which must contain nucleic acids (either DNA, RNA, or both)." https://lnkd.in/eAmJb_G View in LinkedIn
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linkedin post 2016-01-08 06:50:33

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"PRIONS are not considered living organisms because they are misfolded protein molecules which may propagate by transmitting a misfolded protein state. If a prion enters a healthy organism, it induces existing, properly folded proteins to convert into the misfolded prion form. In this way, the prion acts as a template to guide the misfolding of more proteins into prion form." https://en.m.wikipedia.org/wiki/Prion View in LinkedIn
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