linkedin post 2016-02-06 05:37:27
"SUPER ENHANCERS are enhancer-dense regions found near genes that play key roles in determining cellular identity." https://lnkd.in/eBuSbSN View in LinkedIn
linkedin post 2016-02-06 05:38:42
KEY GENES. "Recent studies suggest that key genes regulating cell type-specific functions reside in enhancer-dense genomic regions (i.e., super enhancers, stretch enhancers)." https://lnkd.in/eui_mzh View in LinkedIn
linkedin post 2016-02-06 05:40:08
THE BEAUTY PARADE. "We have generated a catalogue of super-enhancers in 86 human cell and tissue types and shown that these are associated with genes encoding cell type-specific transcription factors and other components that play important roles in cell type-specific biology." https://lnkd.in/eTiMHmY View in LinkedIn
linkedin post 2016-02-06 05:43:07
SUPER-ENHANCERS AS DISEASE HOT-SPOTS. "These results confirm that much of disease-associated DNA sequence variation occurs in transcriptional regulatory regions of the genome, indicate that most of this variation occurs in enhancers, and reveal that variation disproportionately impacts super-enhancer domains." https://lnkd.in/eY3t4KN View in LinkedIn
linkedin post 2016-02-06 05:47:08
TOP HIERARCHY. "Our working theory is that we don’t need to study all 10,000 genes expressed in a cell...Super-enhancers will point us to ones that are the most important.” https://lnkd.in/ezRUFD5 View in LinkedIn
linkedin post 2016-02-06 05:48:45
ELITE DRIVERS. "Because only 1 to 2 percent of active genes are physically linked to a super-enhancer, mapping the locations of super-enhancers can be used to pinpoint the small number of genes that may drive the biology of that cell." https://lnkd.in/esCre5j View in LinkedIn
linkedin post 2016-02-06 05:50:53
DUAL OUTCOMES. "Super-enhancers play important roles in normal development, although their aberrant assembly can enhance the abnormal expression of key genes and contribute to multiple diseases including Alzheimer's disease, type 1 diabetes mellitus and cancers." https://lnkd.in/e6cA5kH View in LinkedIn
linkedin post 2016-02-06 05:54:16
"SEA: a super-enhancer archive. The current release of SEA incorporates 83,996 super-enhancers computationally or experimentally identified in 134 cell types/tissues/diseases." This appears to be an ungovernable committee of genes. http://nar.oxfordjournals.org/content/early/2015/11/16/nar.gkv1243.full View in LinkedIn
linkedin post 2016-02-07 05:46:54
"ENHANCED ENHANCERS. The recent discovery of super-enhancers may offer new drug targets for a range of diseases." https://lnkd.in/esCre5j View in LinkedIn
linkedin post 2016-02-07 05:48:26
NEW DIAGNOSTICS AND THERAPEUTICS. "Super-enhancers can be used as potential biomarkers for disease diagnosis and therapeutics. Current studies have identified super-enhancers in more than 100 cell types and demonstrated their functional importance." https://lnkd.in/eSAYCfF View in LinkedIn