Month: September 2022

TWO LIFE STRATEGIES. "We have extensive mechanisms to proof-read our DNA and keep out errors. Viruses skip this and accumulate errors at a high rate. Some viral errors mean that they cannot complete their life cycle. These are called defective viruses." https://lnkd.in/eV3d7kz View in LinkedIn

DNA REPLICATION ANIMATION. Complexity reduced to beauty. A picture animation is worth a thousand words. A must-see. Show your children. https://lnkd.in/ez8JfGr View in LinkedIn

DNA PACKAGING into chromosomes, the next step. Another brilliant animation. https://lnkd.in/efNVEqJ View in LinkedIn

PROTEIN BLUEPRINT. "DNA serves as a stable information storage medium and every protein which is needed by the cell is produced from this blueprint via an RNA intermediate code." https://lnkd.in/eJg7ubh View in LinkedIn

REPLICATION FIDELITY. "The integrity of the human genome depends on numerous processes that determine the fidelity of DNA replication." https://lnkd.in/euw7dRD View in LinkedIn

CONSERVED IN EVOLUTION. "Eukaryotes replicate their DNA with remarkable accuracy. This accuracy is achieved through a network of conserved pathways that repair DNA damage and correct DNA polymerase errors." https://lnkd.in/ewJXZkd View in LinkedIn

INTEGRITY OF INHERITANCE. "A fundamental aspect of life lies in maintaining the integrity of the genome, ensuring the correct inheritance of the genetic information." https://lnkd.in/eNytTdX View in LinkedIn

DNA POLYMERASE copies DNA with an error rate in copying of only 1 error per 10(5) base pairs. But the human genome has 6 X 10(9) base pairs. Thus equivalent to 60,000 errors per genome. How does the cell remedy this lopsided equation? https://lnkd.in/eDr47d6 View in LinkedIn

DNA POLYMERASE PROOFREADING at 1 error per 10(7) base pairs. With 6 X 10(9) base pairs in the human genome this still means 600 errors. https://lnkd.in/eDr47d6 View in LinkedIn

DNA POLYMERASE plus proofreading with 1 error in 10(7) base pairs; plus mismatch repair (MMR) is 1 error in 10(9) base pairs; and with 6 X 10(9) base pairs per human genome this means only ~6 errors in the genome. https://lnkd.in/eDr47d6 View in LinkedIn