Month: September 2022

"THE PERSISTENT LIFESTYLE allows the virus to transmit complex viral phenotypes to the host organism. This process, which changes both the genetic identity of the host and the identity of its persistent settler, enables the host to broaden its evolutionary adaptational potential and may promote the formation of new species." https://lnkd.in/euyhznh View in LinkedIn

NARROW CYCLE WINDOWS. "Endogenous retroviral competences in the persistent status are often characterized by features expressed only in the strict time window of a developmental process, such as axis formation, trophectoplast formation, or the S phase of the cell cycle." https://lnkd.in/euyhznh View in LinkedIn

NATURAL WASTE. "It may seem strange that plants and animals have evolved such an elaborate system to prevent the use of certain mRNAs. The notion that perfectly good nucleic acids are degraded after they are transcribed seems even wasteful at times." http://onlinelibrary.wiley.com/doi/10.1002/stem.1922/full View in LinkedIn

HISTORICAL DEFICIENCY. "MicroRNAs were likely implemented throughout evolution due to inherent deficiencies in gene expression regulation. Such inadequacies could have otherwise hindered the emergence of complex organisms referring to the evolution of vertebrates and mammals in particular." http://onlinelibrary.wiley.com/doi/10.1002/stem.1922/full View in LinkedIn

EXQUISITE FLEXIBILITY. ""The complex nature of microRNAs implies that they are capable of achieving amazing regulation of cellular function. For example, microRNAs have even been demonstrated to regulate vertebrate embryonic development through managing gradient expression." http://onlinelibrary.wiley.com/doi/10.1002/stem.1922/full View in LinkedIn

GENE REGULATION. "The regulation of gene expression is of fundamental importance to maintain organismal function and integrity and requires a multifaceted and highly ordered sequence of events. The cyclic nature of gene expression is known as ‘transcription dynamics’. Disruption or perturbation of these dynamics can result in significant fitness costs arising from genome instability, accelerated ageing and disease." https://lnkd.in/eRcyMDJ View in LinkedIn

MICROGUARDING. "We review recent research that supports the idea that an important new role for small RNAs, particularly microRNAs (miRNAs), is in protecting the genome against short-term transcriptional fluctuations, in a process we term ‘microguarding’." https://lnkd.in/eRcyMDJ View in LinkedIn

COMPLEX REPRODUCTION. "Microguarding to buffer against interactions with the opposite sex. Reproduction involves a complex series of choreographed events that must occur in the correct sequence in order for eggs to be produced, fertilised and laid/implanted." https://lnkd.in/eRcyMDJ View in LinkedIn

EPIGENETICS NUANCES GENETIC SYNTAX. "The interesting thing is that the variety of parts that constitute the phenotype throughout its developmental stages as well as its regulation is coded in the genotype together with epigenetic markings. Epigenetics is an effective tool for expanding the informational content of a given nucleotide sequence syntax with multiple meanings/functions." https://lnkd.in/eg6uePF View in LinkedIn

GENOTYPE AND PHENOTYPE SPLIT. "RNA world agents: where the genotype is the phenotype. With the split into a RNA world and a DNA world that codes for proteins with a non-repeat genetic syntax the split between the genotype and the phenotype emerged." https://lnkd.in/eg6uePF View in LinkedIn