Year: 2022

PRION LOGIC. "And prions are just proteins. No genetic material. So, logically, prions cannot cause infection. But prions have their own form of logic." Humbling, and contrary to traditional thinking about inheritance and infectivity. https://lnkd.in/ekPJGXx View in LinkedIn

PRION PROTEIN GENES. "I was able to discover that yeast has prions (infectious proteins), proteins that are the carriers of genetic information, and thus are acting as genes...(our work) established that there are such things as genes made of protein, and led to an understanding of how proteins can encode and transmit heritable information." https://lnkd.in/eTW5Tb4 View in LinkedIn

PRIONS IN PLANTS. "the LD protein is involved in the “vernalization” phenomenon, an example of epigenetic “memory” of previous environmental changes. The term “vernalization,” known for about a century, refers to triggering the flowering and reproduction process after the exposure to cold weather.” (LD = a protein named Luminidependens). https://lnkd.in/dbkpYBx View in LinkedIn

"MATERNAL EFFECT on phenotype. mRNA transcripts stored in the egg prior to fertilization influence phenotype of the individual after fertilization by a sperm." https://lnkd.in/dBcZ4KZ View in LinkedIn

NONGENETIC INHERITANCE. "There is accumulating evidence for nongenetic transgenerational inheritance with conspicuous marked sexual dimorphism for both the modes of transmission and the effects." https://lnkd.in/dfvU9Q7 View in LinkedIn

"SINGLE GENE DISORDERS with Mendelian inheritance patterns have contributed greatly to the identification of genes and pathways implicated in genetic disease. In these cases, molecular analysis predicts disease status relatively directly. However, there are many abnormalities which show familial recurrence and have a clear genetic component, but do not show regular Mendelian segregation patterns." http://hmg.oxfordjournals.org/content/13/suppl_2/R225.full View in LinkedIn

NON-MENDELIAN INHERITANCE examples include over 50 diseases, caused by: incomplete penetrance, allele interaction, epigenetic triggers, unusual segregation patterns, variable expressivity, twin effects, segregation distortion, triplet repeat expansion, telomere shortening, cryptic telomeres alleles, and maternal inheritance and heteroplasmy. Discussed in detail in this excellent review. http://hmg.oxfordjournals.org/content/13/suppl_2/R225.full View in LinkedIn

NON-MENDELIAN INHERITANCE. "The meaning of paramutation in the life cycle and in evolution remains to be determined even though we might conjecture that this phenomenon could be involved in a fast heritability of favourable epigenetic states across generations in a non-Mendelian way." https://lnkd.in/daR66WW View in LinkedIn

PARAMUTATION. "RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Paramutation is a heritable epigenetic modification induced in plants by cross-talk between allelic loci." https://lnkd.in/ddBDzkj View in LinkedIn

VIOLATED LAW. "In epigenetics, a paramutation is an interaction between two alleles at a single locus, whereby one allele induces a heritable change in the other allele. This change is meiotically inheritable, and therefore paramutation violates Mendel’s first law." https://lnkd.in/eTKtQvg View in LinkedIn