Year: 2022

"YEAST PRIONS: Paramutation at the protein level? Prionogenesis can confer both loss-of-function and gain-of-function properties to the prion protein and this in turn can have a major impact on host phenotype, short-term adaptation and evolution of new traits." https://lnkd.in/eyrvJwi View in LinkedIn

ALLELE INTERACTIONS. "Paramutation: Just a Curiosity or Fine Tuning of Gene Expression in the Next Generation? Among the epigenetic events, paramutation occurs when a silenced allele (named paramutagenic) is able to silence another allele (paramutable) in trans and this change is heritable. The silenced paramutable allele acquires paramutagenic capacity in the next generations." https://lnkd.in/daR66WW View in LinkedIn

MENDEL'S LAW AND TRANSPOSONS. "In the 1940s Barbara McClintock was one of the first scientists to find exceptions to Mendel’s laws while working on anthocyanin pigments in maize: this work led to the discovery of transposons and to the Nobel prize in 1983." https://lnkd.in/daR66WW View in LinkedIn

NON DNA INHERITANCE. "In particular the epigenetic phenomena defined by Riggs and colleagues as “the study of mitotically and/or meiotically heritable changes in gene function that cannot be explained by changes in DNA sequence” have disclosed a new level of gene regulation." https://lnkd.in/daR66WW View in LinkedIn

EPIGENETICS IS WIDESPREAD. "These phenomena seem as if they may exist in all phyla, and control a number of gene regulation processes ranging from embryo development to human diseases by DNA methylation, chromatin modification (histone methylation and nucleosome position) and noncoding RNA." https://lnkd.in/daR66WW View in LinkedIn

DIGITAL TO ANALOG. "Paramutation generates different epialleles silenced with variable phenotypes due to modulation of gene expression, leading to a change in the conception of gene expression from a digital system (the classical mutations) to an analog system (epialleles)." https://lnkd.in/daR66WW View in LinkedIn

“EPIGENETIC SIGNALS are responsible for the establishment, maintenance and reversal of metastable transcriptional states that are fundamental for the cell's ability to “remember” past events, such as changes in the external environment or developmental cues.” https://lnkd.in/dteycy7 View in LinkedIn

TURNED ON GENE SUBSET. "Cell specialization in complex organisms is possible by fine tuning of genome expression because all the cells of a multicellular organism carry the same DNA information but only a small sub-set of the genes must be active at a certain point of development and growth." https://lnkd.in/daR66WW View in LinkedIn

GENE SUBSET INHERITANCE. "This “molecular memory” regarding the level of expression of every gene must be faithfully transmitted through cell division while also allowing the adaptation of the organism to the environmental stimuli during its life." https://lnkd.in/daR66WW View in LinkedIn

GENE SUBSET MECHANISM. "The mechanism involved in this self-propagating memory can be divided into two classes: the cis-acting signals physically associated with the gene that they regulate and the trans-acting signals." https://lnkd.in/daR66WW View in LinkedIn