Year: 2022

ON AND OFF SWITCHES. "The ICE carries histone modifications that are specific to the DNA-methylated allele, i.e., repressive histone marks are associated with the DNA-methylated ICE, whereas active histone marks are associated with the unmethylated ICE." (ICE = imprint control element). " "Munshi A, Mohan V and Ahuja YR View in LinkedIn

"X-INACTIVATION (also called lyonization) is a process by which one of the copies of the X chromosome present in female mammals is inactivated. The coloration of tortoiseshell and calico cats is a visible manifestation of X-inactivation." https://lnkd.in/dx_V4hK View in LinkedIn

DOSAGE EFFECT. "X-chromosome inactivation in female mammals is epigenetic dosage compensation by an unknown mechanism."" "Munshi A, Mohan V and Ahuja YR View in LinkedIn

LONG NON-CODING RNAs. "Long ncRNAs are not only limited to regulating the expression of protein-coding genes, but also are involved in regulating the expression of other long ncRNAs."" "Munshi A, Mohan V and Ahuja YR View in LinkedIn

KEY IN EPIGENETICS. “Thousands of lncRNAs have emerged as key molecular players in epigenetic processes through their association with chromatin modifiers. Specifically, antisense RNAs in the nucleus can act as regulators of their counterpart sense mRNA by modulating chromatin structure in cis and by bridging epigenetic effectors and regulatory complexes at specific genomic loci.” http://www.mdpi.com/1422-0067/16/2/3251/htm View in LinkedIn

KEY REGULATORS. “lncRNAs are mainly associated with proteins due to the possession of distinct protein-binding domains. Such complexes may have an impact on transcription, acting as key regulators of gene expression.” https://lnkd.in/ef6MAfH View in LinkedIn

KEY REGULATORS. “lncRNAs are mainly associated with proteins due to the possession of distinct protein-binding domains. Such complexes may have an impact on transcription, acting as key regulators of gene expression.” View in LinkedIn

Ref for key regulators and next post: https://lnkd.in/ef6MAfH http://www.mdpi.com/1422-0067/16/2/3251/htm View in LinkedIn

MOLECULAR DECOYS. lncRNAs can function as molecular decoys, with sponge-like properties, taking away proteins from a specific location or recruiting proteins to activate or inhibit processes involved at any level of gene regulation.” https://lnkd.in/ef6MAfH View in LinkedIn

NEW FUNCTIONS. “Miscellaneous RNA–protein interactions can support the assembly of protein complexes (scaffold), which link the factors together in order to generate brand new functions that may impact the process of transcription, either positively or negatively.” http://www.mdpi.com/1422-0067/16/2/3251/htm View in LinkedIn