Year: 2022

LIMITED RESOURCES. "Consequently, the number and the life expectancy of a B-cell clone vary according to the presence or absence of competitor populations. This process of lymphocyte competition is likely controlled by a common need for resources that are in limited supply." http://onlinelibrary.wiley.com/doi/10.1111/j.0105-2896.2004.0095.x/full View in LinkedIn

BRAIN METABOLISM WINS. "Here we present a new paradigm for the regulation of energy supply within the organism. The brain gives priority to regulating its own adenosine triphosphate (ATP) concentration. In that postulate, the peripheral energy supply is only of secondary importance." https://lnkd.in/dFnjHSQ View in LinkedIn

NUTRIENT FUNNELING TO BRAIN. "The brain has two possibilities to ensure its energy supply: allocation or intake of nutrients. The term ‘allocation’ refers to the allocation of energy resources between the brain and the periphery." http://www.sciencedirect.com/science/article/pii/S0149763404000259 View in LinkedIn

SELFISH BRAIN. "The presented model includes a newly discovered ‘principle of balance’ of how pairs of high and low-affinity receptors can originate setpoints in biological systems. In this ‘Selfish Brain Theory’, the neocortex and limbic system play a central role in the pathogenesis of diseases such as anorexia nervosa and obesity." View in LinkedIn

https://lnkd.in/dFnjHSQ http://www.sciencedirect.com/science/article/pii/S0149763404000259 View in LinkedIn

SELFISH BRAIN. "The presented model includes a newly discovered ‘principle of balance’ of how pairs of high and low-affinity receptors can originate setpoints in biological systems. In this ‘Selfish Brain Theory’, the neocortex and limbic system play a central role in the pathogenesis of diseases such as anorexia nervosa and obesity." http://www.sciencedirect.com/science/article/pii/S0149763404000259 View in LinkedIn

SECOND MAJOR FORCE. "Repression of competition within groups joins kin selection as the second major force in the history of life shaping the evolution of cooperation. When opportunities for competition against neighbors are limited within groups, individuals can increase their own success only by enhancing the efficiency and productivity of their group." https://lnkd.in/duWA75V View in LinkedIn

CHEMICAL DARWINIAN COMPETITION. “In recent years, an extension of the Darwinian framework is being considered for the study of prebiotic chemical evolution, shifting the attention from homogeneous populations of naked molecular species to populations of heterogeneous, compartmentalized and functionally integrated assemblies of molecules.” https://lnkd.in/d-UDSAh View in LinkedIn

SO ENDS this curated dip into biological resource allocation. While Darwinian competition for limited resources has been documented at the ecological, population, cellular and intracellular level, it comes as no surprise that it exists at molecular levels also. The triumph of the fittest at each level must have different drivers. At the molecular level it must be reaction kinetics based on molecular shapes, while at population levels it is about successfully generating viable offspring. At what point competition and cooperation overlap is the interesting question. View in LinkedIn

GENERATING UNIQUENESS. “Meiosis, from the Greek word meioun, meaning "to make small," refers to the specialized process by which germ cells divide to produce gametes. Because the chromosome number of a species remains the same from one generation to the next, the chromosome number of germ cells must be reduced by half during meiosis. To accomplish this feat, meiosis, unlike mitosis, involves a single round of DNA replication followed by two rounds of cell division. Meiosis also differs from mitosis in that it involves a process known as recombination, during which chromosomes exchange segments with one another. As a result, the gametes produced during meiosis are genetically unique.” https://lnkd.in/dBpemgQ View in LinkedIn