linkedin post 2018-10-27 05:12:57

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ANOTHER EXEMPLAR. "The most compelling evidence of the dominance of genome reduction and simplification was obtained through the reconstruction of the genomic evolution of archaea that almost exclusively are free-living organisms. The latest ML reconstruction based on a comparative analysis of 120 archaeal genomes traced between 1,400 and 1,800 gene families to the last common ancestor of the extant archaea." (ML = maximum likelihood methods). http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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linkedin post 2018-10-27 05:14:42

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SNAKES AND LADDERS. "Given the fractions of conserved and lineage-specific genes in modern archaeal genomes, this translates into approximately 2,500 genes in the ancestral genome, which is a larger genome than most of the extant archaea possess. The reconstructed pattern of gene loss and gain in archaea is non-trivial: there seems to have been some net gene gain at the base of each of the major archaeal branches that was almost invariably followed by substantial gene loss...this could be a general pattern of genome evolution." http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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linkedin post 2018-10-27 05:18:25

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WIDESPREAD LOSS. "Even animals and plants, the eukaryotic kingdoms that seem to be the least prone to gene loss, have lost about 20% of the putative ancestral genes identified in the unicellular Naegleria. Collectively, these findings imply that the genome of the LECA was at least as complex as the genomes of typical extant free-living unicellular eukaryotes." (LECA = last eukaryotic common ancestor). http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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linkedin post 2018-10-27 05:20:03

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EUKARYOTE LOSSES. "Even more striking conclusions were reached by the reconstruction of the evolution of the eukaryotic protein domain repertoire that involved comparison of 114 genomes. The results of this reconstruction indicate that most of the major eukaryotic lineages have experienced a net loss of domains that have been traced to the LECA." (LECA = last eukaryotic common ancestor). http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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linkedin post 2018-10-28 02:47:34

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CORROBORATIVE RESULTS. "Remarkably congruent results have been obtained in reconstructions of the gain and loss of introns in eukaryotic genes. In this case, the availability of thousands intron positions provide for the use of powerful ML methods." (ML = maximum likelihood methods). http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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linkedin post 2018-10-28 02:48:54

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THE INTRON FACTOR. "The reconstructions consistently indicate that ancestral eukaryotes including the LECA and the founders of each supergroup were intron-rich forms, with intron densities higher than those in the genes of most extant eukaryotes and probably only slightly lower than those in the modern organisms with the most complex gene structures, such as mammals." (LECA = last eukaryotic common ancestor). http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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linkedin post 2018-10-28 02:59:14

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MASSIVE INTRON LOSS. "Remarkably, intron-rich ancestors were reconstructed even for those major groups of eukaryotes that currently consist entirely of intron-poor forms such as the alveolates that apparently evolved via differential, lineage-specific, extensive intron loss." http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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linkedin post 2018-10-28 03:00:33

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INTRON LOSS DOMINATION. "All in all, intron loss clearly dominated the evolution of eukaryotic genes, with episodes of substantial gain linked only with the emergence of some major groups, especially animals, in full agreement with the results of the evolutionary reconstruction for the eukaryotic domain repertoire." http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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linkedin post 2018-10-28 03:02:08

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MORE EQUAL PARTNER. "Simplification could be an “an equal partner to complexification” in the evolution of eukaryotes. The latest reconstruction results suggest that simplification could be even “more equal” than complexification." http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn
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