Year: 2022

CODE ERROR. "I practically watched what every relevant thing was doing in GEAR to try and pinpoint what was going wrong. At around clock tick 25000 or so, the main memory would just clear itself, almost all of it, including the cog0 program itself. Woops on the forgetting to reset the index! After enough loops, the index would eventually plow right through VAR and PUB, rewriting the main program memory with audio data. Quite the epic fail for such a simple mistake." https://lnkd.in/dbpGw4Q View in LinkedIn

FRAGMENT FROM NATURE concludes this weekend on the topic of the evolution of metabolism. To look at a wall chart summarizing metabolic pathways is to experience a sense of awe at the sheer complication of nature’s devices. It seems like an ultra-sophisticated wiring chart, with failsafe backups, and elegant binary pathways. But an evolutionary perspective allows the view of monumental redundancies, work-arounds, bolt-ons, and simple vestigial shunts. After all, it was not purpose built from scratch, but was the consequence of monumental accidents. View in LinkedIn

MUTANT ENZYMES. "Extant natural products arose from mutations of enzymes involved in the synthesis of primary metabolites." https://lnkd.in/dEpJBda View in LinkedIn

MOLECULAR ECOLOGY. "The natural products that emerged over time were modified by variants of other enzymes involved in primary metabolism in a gene-for-gene fashion with other biological components of the ecosystem." https://lnkd.in/dEpJBda View in LinkedIn

SIMPLE SIGNALS. "Under the pressure of natural selection, natural products evolved as messages, defined in broad terms, i.e. come hither, don't eat me, germinate, divide, attach, disengage, etc." https://lnkd.in/dEpJBda View in LinkedIn

CHUNKING. "Horizontal transfer of genes (that code for biosynthetic pathways) between species occurred and conferred selective advantages to organisms." https://lnkd.in/dEpJBda View in LinkedIn

ACTIONS AND FUNCTIONS. “The actions of natural products in human physiology are often not relevant to their function(s) in the producing organisms." https://lnkd.in/dEpJBda View in LinkedIn

INTERMEDIATES. "The bewildering array of structure types resulting from these processes...can be traced to the versatility of the various enzyme systems operating through reactive intermediate carbonations." https://lnkd.in/dEpJBda View in LinkedIn

LOGICALAL PROKARYOTIC STRUCTURES. "In prokaryotes, the genes for metabolic pathways are typically organized into operons and, upon transcription, give polycistronic m-RNA. Such unidirectional, clustered, and organized genes would appear to make good engineering sense." https://lnkd.in/dEpJBda View in LinkedIn

PROKARYOTE LOGIC. "Not only are the genes aligned sequentially...but they are also usually aligned along the same direction in the DNA strand." https://lnkd.in/dEpJBda View in LinkedIn